Hematology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain.
Fundación INCLIVA, Instituto de Investigación Sanitaria Hospital Clínico Universitario de Valencia, Valencia, Spain.
Transpl Infect Dis. 2023 Nov;25 Suppl 1:e14117. doi: 10.1111/tid.14117. Epub 2023 Aug 16.
Before the COVID-19 pandemic, common community-acquired seasonal respiratory viruses (CARVs) were a significant threat to the health and well-being of allogeneic hematopoietic cell transplant (allo-HCT) recipients, often resulting in severe illness and even death. The pandemic has further highlighted the significant risk that immunosuppressed patients, including allo-HCT recipients, face when infected with SARS-CoV-2. As preventive transmission measures are relaxed and CARVs circulate again among the community, including in allo-HSCT recipients, it is crucial to understand the current state of knowledge, gaps, and recent advances regarding CARV infection in allo-HCT recipients. Urgent research is needed to identify seasonal respiratory viruses as potential drivers for future pandemics.
在 COVID-19 大流行之前，常见的社区获得性季节性呼吸道病毒 (CARV) 对异基因造血细胞移植 (allo-HCT) 受者的健康和福祉构成重大威胁，经常导致严重疾病甚至死亡。大流行进一步凸显了包括 allo-HCT 受者在内的免疫抑制患者在感染 SARS-CoV-2 时面临的巨大风险。随着预防传播措施的放宽，以及 CARVs 在社区中再次传播，包括 allo-HSCT 受者，了解 allo-HCT 受者中 CARV 感染的现有知识状态、差距和最新进展至关重要。迫切需要开展研究，以确定季节性呼吸道病毒是否可能成为未来大流行的潜在驱动因素。
