Department of Stomatology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, P.R. China.
Department of Oral Pathology, School of Stomatology, Hainan Medical University, Haikou, P.R. China.
Viral Immunol. 2023 Sep;36(7):438-448. doi: 10.1089/vim.2023.0044. Epub 2023 Aug 16.
Both absent in melanoma 2 () and interferon-inducible protein 16 () are intracellular innate immune receptors that recognize double-stranded DNA released during pathogenic infection, leading to the assembly of the inflammasome. The assembly of the inflammasome results in the secretion of bioactive interleukin (IL)-1 and IL-18 and induces cell death through an inflammatory process called pyroptosis. Although the inflammasome is generally harmful in the context of some aseptic inflammatory illnesses, it plays a protective role in infectious diseases. During inflammatory processes, there is competition between and . In this review, we explore the impacts of and in infectious disease and aseptic inflammation, respectively, and how they compete.
两种缺失均存在于黑色素瘤 2 () 和干扰素诱导蛋白 16 () 中，它们都是识别致病性感染过程中释放的双链 DNA 的细胞内先天免疫受体，导致炎性小体的组装。炎性小体的组装导致生物活性白细胞介素 (IL)-1 和 IL-18 的分泌，并通过一种称为细胞焦亡的炎症过程诱导细胞死亡。尽管在一些无菌性炎症疾病的背景下，炎性小体通常是有害的，但它在传染病中起着保护作用。在炎症过程中， 和 之间存在竞争。在这篇综述中，我们分别探讨了 和 在传染病和无菌性炎症中的作用以及它们之间的竞争。
