Effects of and on Infectious Diseases and Inflammation.

Both absent in melanoma 2 () and interferon-inducible protein 16 () are intracellular innate immune receptors that recognize double-stranded DNA released during pathogenic infection, leading to the assembly of the inflammasome. The assembly of the inflammasome results in the secretion of bioactive interleukin (IL)-1 and IL-18 and induces cell death through an inflammatory process called pyroptosis. Although the inflammasome is generally harmful in the context of some aseptic inflammatory illnesses, it plays a protective role in infectious diseases. During inflammatory processes, there is competition between and . In this review, we explore the impacts of and in infectious disease and aseptic inflammation, respectively, and how they compete.