Department of Endoscopy Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, 100142, China.
VIP-II Division of Medical Department, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Immunotherapy. 2023 Oct;15(15):1293-1308. doi: 10.2217/imt-2023-0096. Epub 2023 Aug 10.
Our study aimed to identify the role of COL10A1 in colon cancer, including interaction with immune infiltrates and somatic mutations. COL10A1 expression and prognostic value were assessed. Correlations between COL10A1 and various immune parameters were conducted by bioinformatic analysis. Our study demonstrated that COL10A1 is overexpressed in colon cancer and correlates with poor patient survival. The expression level of COL10A1 is significantly associated with mismatch repair deficiency and immune infiltration. High expression of COL10A1 may confer greater sensitivity to anti-PD-1 treatment in colon cancer patients. COL10A1 is a potential diagnostic biomarker associated with deficient mismatch repair and immune infiltration in colon cancer.
我们的研究旨在确定 COL10A1 在结肠癌中的作用，包括与免疫浸润和体细胞突变的相互作用。评估了 COL10A1 的表达和预后价值。通过生物信息学分析研究了 COL10A1 与各种免疫参数之间的相关性。我们的研究表明，COL10A1 在结肠癌中过度表达，与患者生存不良相关。COL10A1 的表达水平与错配修复缺陷和免疫浸润显著相关。COL10A1 的高表达可能使结肠癌患者对抗 PD-1 治疗更敏感。COL10A1 是一种潜在的诊断生物标志物，与结肠癌中错配修复缺陷和免疫浸润有关。
