Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China.
Nanophotonics Research Center, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China.
Anal Chem. 2023 Sep 5;95(35):13338-13345. doi: 10.1021/acs.analchem.3c02648. Epub 2023 Aug 16.
is a good source of astaxanthin, which reduces oxidation in the human body, treats inflammation, and slows the growth of breast and skin cancer cells. Since the size of is often closely related to astaxanthin yield, size-based microalgal separation has far-reaching significance for high-value algae extraction and algal directed evolution. In this work, we report a novel size-tunable elasto-inertial sorting of in the Ecoflex ultrastretchable microfluidic devices. Ecoflex microfluidic chips can deform and be flexible, bringing flexibility and stretchability to microchannels as well as new possibilities for large-scale modulation of channel geometry. Here, the effects of velocity, channel elongation, and particle size on the elasto-inertial migration of particles are systematically studied. We found that channel elongation has a strong regulating effect on particle focusing. In addition, we verified the continuous regulation of the sorting threshold of microalgal cells by stretching the channel, providing technical support for the extraction and directed evolution of high-yield microalgae.
是虾青素的良好来源，虾青素可以减少人体氧化，治疗炎症，减缓乳腺癌和皮肤癌细胞的生长。由于 的大小通常与虾青素的产量密切相关，因此基于大小的微藻分离对高价值藻类提取和藻类定向进化具有深远的意义。在这项工作中，我们报告了一种在 Ecoflex 超弹性微流控装置中可调节大小的弹弹性惯性分选 。Ecoflex 微流控芯片可以变形和具有柔韧性，为微通道带来了灵活性和可拉伸性，为大规模调制通道几何形状提供了新的可能性。在这里，系统地研究了速度、通道伸长率和颗粒大小对颗粒弹弹性迁移的影响。我们发现通道伸长率对颗粒聚焦有很强的调节作用。此外，我们通过拉伸通道验证了微藻细胞分选阈值的连续调节，为高产量微藻的提取和定向进化提供了技术支持。
