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经肋间神经阻滞的区域麻醉与微创开胸心脏手术患者的转归改善相关。

Regional Anesthesia With Paravertebral Blockade Is Associated With Improved Outcomes in Patients Undergoing Minithoracotomy Cardiac Surgery.

机构信息

Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, BC, Canada.

University of British Columbia, Vancouver, BC, Canada.

出版信息

Innovations (Phila). 2023 Jul-Aug;18(4):357-364. doi: 10.1177/15569845231190638. Epub 2023 Aug 10.

Abstract

OBJECTIVE

Severe postoperative pain has been shown to affect many patients following minimally invasive cardiac surgeries (MICS). Multimodal pain management with regional anesthesia, particularly by delivery of local anesthetics using a paravertebral catheter (PVC), has been shown to reduce pain in operations involving thoracotomy incisions. However, few studies have reported high-quality safety and efficacy outcomes of PVCs following MICS.

METHODS

Patients who underwent MICS at Vancouver General Hospital between 2016 and 2019 ( = 123) were reviewed for perioperative opioid-narcotic use. Primary outcomes were postoperative opioid use and hospital length of stay (LOS). Statistical analyses were performed using univariate and multivariable regression models to determine independent risk factors.

RESULTS

A total of 54 patients received routine systemic analgesia (control), 53 patients received a paravertebral catheter (PVC), and 16 patients received another mode of regional analgesia (non-PVC). The mean hospital LOS was significantly different in patients in the PVC group at 5.8 ± 2.0 days versus 8.3 ± 7.1 days in the control and 6.6 ± 2.3 days in the non-PVC group ( = 0.033). The percentage of patients who did not require postoperative oxycodone was significantly higher in the PVC group (48.1%), compared with the control (24.5%) and non-PVC (37.5%; = 0.043) groups.

CONCLUSIONS

The administration of regional anesthesia using PVCs was associated with reduced need for opioids and a shorter LOS. The reduction in postoperative opioids may reduce the risk of potential opioid dependency in this population. Future studies should involve randomized controlled trials with systematic evaluation of pain scores to verify current study results.

摘要

目的

微创心脏手术(MICS)后,许多患者会出现严重的术后疼痛。采用区域麻醉的多模式疼痛管理,特别是通过使用椎旁导管(PVC)给予局部麻醉剂,已被证明可减少开胸切口手术的疼痛。然而,很少有研究报告 MICS 后 PVC 的高质量安全性和疗效结果。

方法

对 2016 年至 2019 年在温哥华综合医院接受 MICS 的患者进行了围手术期阿片类药物使用情况的回顾性分析。主要结果是术后阿片类药物使用和住院时间(LOS)。采用单变量和多变量回归模型进行统计分析,以确定独立的危险因素。

结果

共有 54 例患者接受常规全身镇痛(对照组),53 例患者接受椎旁导管(PVC),16 例患者接受另一种区域镇痛模式(非-PVC)。PVC 组的平均住院 LOS 明显短于对照组(8.3 ± 7.1 天)和非-PVC 组(6.6 ± 2.3 天)(= 0.033)。需要术后羟考酮的患者百分比在 PVC 组明显更高(48.1%),而对照组(24.5%)和非-PVC 组(37.5%)(= 0.043)。

结论

使用 PVC 进行区域麻醉与减少对阿片类药物的需求和缩短 LOS 相关。减少术后阿片类药物的使用可能会降低该人群潜在阿片类药物依赖的风险。未来的研究应包括随机对照试验,并系统评估疼痛评分,以验证当前的研究结果。

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