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超声引导竖脊肌平面阻滞与肋间神经阻滞用于开胸术后急性疼痛管理的随机对照试验。

Ultrasound-Guided Erector Spinae Plane Block Versus Intercostal Nerve Block for Post-Minithoracotomy Acute Pain Management: A Randomized Controlled Trial.

机构信息

Anesthesia and Intensive Care Medicine, Department of Clinical and Surgical Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Anesthesia and Intensive Care Medicine, Department of Clinical and Surgical Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

出版信息

J Cardiothorac Vasc Anesth. 2020 Sep;34(9):2421-2429. doi: 10.1053/j.jvca.2020.01.026. Epub 2020 Jan 21.

Abstract

OBJECTIVE

Several nerve block procedures are available for post-thoracotomy pain management.

DESIGN

In this randomized trial, the authors aimed to determine whether the analgesic effect of preoperative ultrasound-guided erector spinae plane block (ESPB) might be superior to that of intraoperative intercostal nerve block (ICNB) in pain control in patients undergoing minithoracotomy.

SETTING

University hospital.

PARTICIPANTS

Sixty consecutive adult patients scheduled to undergo minithoracotomy for lung resection were enrolled.

INTERVENTIONS

Patients were allocated randomly in a 1:1 ratio to receive either single-shot ESPB or ICNB.

MEASUREMENTS AND MAIN RESULTS

The primary outcome was the intensity of postoperative pain at rest, assessed with the numeric rating scale (NRS). The secondary outcomes were (1) dynamic NRS values (during cough); (2) perioperative analgesic requirements; (3) patient satisfaction, on the basis of a verbal scale (Likert scale); and (4) respiratory muscle strength, considering the maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) variation from baseline. The ESPB group showed lower postoperative static and dynamic NRS values than the ICNB group (p < 0.05). Total remifentanil consumption and requirements for additional analgesics were lower in the ESPB group (p < 0.05). Patient satisfaction was higher in the ESPB group (p < 0.001). A significant overall time effect was found in MIP and MEP variation (p < 0.001); ESPB values were higher at all points, reaching a statistically significant level at the first and sixth hours for MIP, and at the first, 12th, 24th, and 48th hours for MEP (p < 0.05).

CONCLUSIONS

ESPB was demonstrated to provide superior analgesia, lower perioperative analgesic requirements, better patient satisfaction, and less respiratory muscle strength impairment than ICNB in patients undergoing minithoracotomy.

摘要

目的

有几种神经阻滞技术可用于开胸术后疼痛管理。

设计

在这项随机试验中,作者旨在确定术前超声引导竖脊肌平面阻滞(ESPB)在控制接受小开胸术的患者疼痛方面的镇痛效果是否优于术中肋间神经阻滞(ICNB)。

地点

大学医院。

参与者

连续纳入 60 例拟接受小开胸术行肺切除术的成年患者。

干预措施

患者按 1:1 比例随机分配接受单次 ESPB 或 ICNB。

测量和主要结果

主要结局是使用数字评分量表(NRS)评估的术后静息时疼痛强度。次要结局是(1)动态 NRS 值(咳嗽时);(2)围手术期镇痛需求;(3)基于言语量表(Likert 量表)的患者满意度;(4)考虑最大吸气压力(MIP)和最大呼气压力(MEP)从基线的变化,评估呼吸肌力量。ESPB 组术后静态和动态 NRS 值均低于 ICNB 组(p<0.05)。ESPB 组的瑞芬太尼总消耗量和额外镇痛需求较低(p<0.05)。ESPB 组的患者满意度较高(p<0.001)。在 MIP 和 MEP 变化方面,发现了总体时间效应(p<0.001);在所有时间点,ESPB 值均较高,在 MIP 的第 1 和第 6 小时以及 MEP 的第 1、12、24 和 48 小时达到统计学显著水平(p<0.05)。

结论

与 ICNB 相比,ESPB 可提供更好的镇痛效果、更低的围手术期镇痛需求、更高的患者满意度和更低的呼吸肌力量损害,适用于接受小开胸术的患者。

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