Universidade Federal de Pernambuco, Post Graduate in Surgery - Recife (PE), Brazil.
Universidade Federal de Pernambuco, Nutrition Department - Recife (PE), Brazil.
Arq Bras Cir Dig. 2023 Aug 14;36:e1755. doi: 10.1590/0102-672020230037e1755. eCollection 2023.
Weight regain in the postoperative period after bariatric surgery is directly related to the relapse of preoperative comorbidities and a negative impact on the patients' biochemical profile.
To assess the metabolic impact of weight regain on preoperative comorbidities and on patients' biochemical profiles, in order to show the impact of the complications on the metabolic outcomes of bariatric surgery.
A retrospective study was carried out with 75 women in the late postoperative period of bariatric surgery who presented pathological weight regain (≥20% of the maximum weight loss). Data of interest consisted of glycemic, lipid, and inflammatory profile measurements at three different moments of evaluation: preoperative period, at the weight nadir (minimum weight), and after weight regain. A multivariate analysis was performed.
The mean age was 46.39±12.09 years. Preoperative body mass index was 40.10±4.11 kg/m2. There was an overall increase of 3.36 points in the mean body mass index between the nadir and after regain: from 26.30±3.9 kg/m2 to 29.66±4.66 kg/m2. The mean time to reach the nadir was 18±7.6 months, with an average percentage of excess weight loss of 91.08±11.8%. The median time for pathological weight regain was 48 months, and the mean regain amongst the sample was 8.85±5.65 kg. There was a significant correlation between pathological weight regain and levels of insulin (r=0.351; p<0.011), C-peptide (r=0.303; p<0.011), C-reactive protein (r=0.402; p<0.001), and vitamin D (r=-0.435; p<0.001), the last two being the most influenced by the percentage of weight regained.
The pathological weight regain in the postoperative period of bariatric surgery results in losses in the patients' metabolic and inflammatory profiles. However, the biochemical benefits are sustained up to the preoperative levels of the parameters analyzed.
减重手术后的体重反弹与术前合并症的复发直接相关，并对患者的生化指标产生负面影响。
评估体重反弹对术前合并症和患者生化指标的代谢影响，以展示并发症对减重手术代谢结果的影响。
对 75 名接受过减重手术后处于晚期的女性进行了一项回顾性研究，这些女性出现了病理性体重反弹（≥最大减重的 20%）。有意义的数据包括在三个不同评估时间点的血糖、血脂和炎症指标测量值：术前、体重最低点（最低体重）和体重反弹后。进行了多变量分析。
平均年龄为 46.39±12.09 岁。术前体重指数为 40.10±4.11kg/m2。从最低点到反弹后，平均体重指数总体增加了 3.36 个点：从 26.30±3.9kg/m2 增加到 29.66±4.66kg/m2。达到最低点的平均时间为 18±7.6 个月，超重损失的平均百分比为 91.08±11.8%。病理性体重反弹的中位时间为 48 个月，样本中的平均反弹量为 8.85±5.65kg。病理性体重反弹与胰岛素（r=0.351；p<0.011）、C 肽（r=0.303；p<0.011）、C 反应蛋白（r=0.402；p<0.001）和维生素 D（r=-0.435；p<0.001）水平呈显著相关性，后两者受体重反弹百分比的影响最大。
减重手术后的病理性体重反弹导致患者的代谢和炎症指标下降。然而，生化指标的益处保持在分析参数的术前水平。
