白细胞介素 17（IL-17）、肿瘤坏死因子-α（TNF-α）、白细胞介素 10（IL-10）、干扰素-γ（IFN-γ）和白细胞介素 18（IL-18）多态性与土耳其人群乙型肝炎病毒感染结局的关系。

Relationship between IL-17, TNF-α, IL-10, IFN-γ, and IL-18 polymorphisms with the outcome of hepatitis B virus infection in the Turkish population.

机构信息

Suleyman Demirel University, School of Medicine, Department of Infectious Diseases - Isparta, Turkey.

Pamukkale University, School of Medicine, Department of Medical Genetics - Denizli, Turkey.

出版信息

Rev Assoc Med Bras (1992). 2023 Aug 14;69(8):e20230355. doi: 10.1590/1806-9282.20230355. eCollection 2023.

DOI:10.1590/1806-9282.20230355

PMID:37585994

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10427177/

Abstract

OBJECTIVE

Hepatitis B virus is a global threat that can lead to liver cirrhosis and hepatocellular carcinoma. For the treatment of chronic hepatitis B virus, polymorphisms might be an option for gene treatments. This study aimed to investigate the effects of IL-17, TNF-α, IL-10, IFN-γ, and IL-18 gene polymorphisms on hepatitis B virus infection in the Turkish population.

METHODS

The genotypes and allele distribution of 75 patients exposed to hepatitis B virus and 50 healthy control individuals were analyzed. The real-time polymerase chain reaction method was used for identification.

RESULTS

A correlation was observed between susceptibility to hepatitis B virus infection and IL-17 Exon 3/3'UTR (rs1974226) C, IL-17 Exon 3 (rs763780) A, IL-18 (-607) (rs1946518) A alleles, and IL-17 Exon 3 (rs763780) AA genotype (p=0.006, p=0.009, p=0.025, and p=0.008, respectively). Furthermore, IL-18 (-137) (rs187238) TT genotype and TNF-α-308 (rs1800629) G and A alleles, were associated with protection against hepatitis B virus infection (p=0.0351 and p=0.032, respectively).

CONCLUSION

This study demonstrated that TNF-α (-308), IL-17 (Exon 3/3' UTR), IL-17 (Exon 3), and IL-18 (-607) polymorphisms are associated with hepatitis B virus infection. Therefore, these may serve as potential therapeutic targets for chronic viral hepatitis in the Turkish population.

摘要

目的

乙型肝炎病毒是一种全球性威胁，可导致肝硬化和肝细胞癌。对于慢性乙型肝炎病毒的治疗，基因治疗中的多态性可能是一种选择。本研究旨在探讨白细胞介素 17（IL-17）、肿瘤坏死因子-α（TNF-α）、白细胞介素 10（IL-10）、干扰素-γ（IFN-γ）和白细胞介素 18（IL-18）基因多态性对土耳其人群乙型肝炎病毒感染的影响。

方法

分析了 75 例乙型肝炎病毒暴露患者和 50 例健康对照个体的基因型和等位基因分布。采用实时聚合酶链反应方法进行鉴定。

结果

乙型肝炎病毒感染易感性与 IL-17 外显子 3/3'UTR（rs1974226）C、IL-17 外显子 3（rs763780）A、IL-18（-607）（rs1946518）A 等位基因和 IL-17 外显子 3（rs763780）AA 基因型相关（p=0.006、p=0.009、p=0.025 和 p=0.008）。此外，IL-18（-137）（rs187238）TT 基因型和 TNF-α-308（rs1800629）G 和 A 等位基因与乙型肝炎病毒感染的保护相关（p=0.0351 和 p=0.032）。