Czerniel Joanna, Gostyńska Aleksandra, Jańczak Julia, Stawny Maciej
Chair and Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60 - 780 Poznan, Poland.
Chair and Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60 - 780 Poznan, Poland.
Eur J Pharm Biopharm. 2023 Oct;191:36-56. doi: 10.1016/j.ejpb.2023.08.009. Epub 2023 Aug 14.
Nanoemulsions have gained increasing attention in recent years as a drug delivery system due to their ability to improve the solubility and bioavailability of poorly water-soluble drugs. This systematic review aimed to collect and critically analyze recent novelties in developing, designing, and optimizing intravenous nanoemulsions appearing in articles published between 2017 and 2022. The applied methodology involved searching two electronic databases PubMed and Scopus, using the keyword "nanoemulsion" in combination with "intravenous" or "parenteral". The resulting original articles were classified by the method of preparation into different categories. An overview of the current methods used for the preparation of such formulations, including high- and low-energy emulsification, was provided. The advantages and disadvantages of these methods were discussed, as well as their potential impact on the properties of the developed intravenous nanoemulsions. The problem of inconsistency in intravenous nanoemulsion terminology may lead to misunderstandings and misinterpretations of their properties and applications was also undertaken. Finally, the regulatory aspects of intravenous nanoemulsions, the state of the art in the field of intravenous emulsifiers, and the future perspectives were presented.
近年来，纳米乳剂作为一种药物递送系统越来越受到关注，因为它能够提高难溶性药物的溶解度和生物利用度。本系统综述旨在收集并批判性地分析2017年至2022年发表的文章中有关静脉注射纳米乳剂开发、设计和优化方面的最新进展。所采用的方法包括在两个电子数据库PubMed和Scopus中进行检索，使用关键词“纳米乳剂”并结合“静脉注射”或“肠胃外”。将所得的原始文章按制备方法分类到不同类别。提供了目前用于制备此类制剂的方法概述，包括高能和低能乳化法。讨论了这些方法的优缺点，以及它们对所开发的静脉注射纳米乳剂性质的潜在影响。还探讨了静脉注射纳米乳剂术语不一致的问题，这可能导致对其性质和应用的误解和错误解读。最后，介绍了静脉注射纳米乳剂的监管方面、静脉注射乳化剂领域的现状以及未来展望。
