Vidane Arachchige Chamila Samarasinghe Samarasinghe, Krishnan Kannan, John Aitken Robert, Naidu Ravi, Megharaj Mallavarapu
Global Centre for Environmental Remediation, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia; Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE), University of Newcastle, NSW, 2308, Australia; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia.
Global Centre for Environmental Remediation, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, 2308, Australia.
Environ Pollut. 2023 Nov 1;336:122376. doi: 10.1016/j.envpol.2023.122376. Epub 2023 Aug 14.
Nanoparticles have gained considerable attention as one of the pollutants released into the environment through consumer products. This study describes the sub-chronic and generational effects of TiO (rutile) nanoparticles on earthworms over a 252-day duration, with exposure ranging from 0.1 to 1000 mg kg. Results indicate that sub-chronic exposure (28 days) of TiO nanoparticles did not cause notable adverse effects on the weight, reproduction, and tissue accumulation in parent earthworms. However, the F1 generation displayed remarkable growth and maturity retardation during their early developmental stages, even at lower nano-TiO (rutile). Significant impacts on the reproduction of the F1 generation were observed solely at the highest concentration (1000 mg kg), which is predicted to be below the highest exposure scenario. Moreover, long-term (252 days) exposure resulted in considerable bioaccumulation of Ti metal in the F1 generation of E. fetida. This study uncovers the negative effects of TiO rutile nanoparticles on earthworms across two generations, with pronounced effects on the growth, maturity, and bioaccumulation in the F1 generation compared to the parent generation. These findings suggest the potential induction of toxic effects by TiO rutile nanoparticles, emphasizing the sensitivity of juvenile parameters over adult parameters in toxicity assessments. Furthermore, the study highlights the urgent need for comprehensive evaluations of the longer-term toxicity of nanoparticles on terrestrial organisms. Implementing multigenerational studies will contribute significantly to a better understanding of nanoparticle ecotoxicity on environmental organisms.
纳米颗粒作为通过消费品释放到环境中的污染物之一，已受到广泛关注。本研究描述了金红石型二氧化钛纳米颗粒在252天内对蚯蚓的亚慢性和代际影响，暴露剂量范围为0.1至1000毫克/千克。结果表明，亚慢性暴露（28天）的二氧化钛纳米颗粒对亲代蚯蚓的体重、繁殖和组织积累没有造成显著的不利影响。然而，即使在较低的纳米二氧化钛（金红石型）浓度下，F1代在其早期发育阶段也表现出显著的生长和成熟迟缓。仅在最高浓度（1000毫克/千克）下观察到对F1代繁殖有显著影响，预计该浓度低于最高暴露情况。此外，长期（252天）暴露导致F1代赤子爱胜蚓中钛金属大量生物累积。本研究揭示了金红石型二氧化钛纳米颗粒对蚯蚓两代的负面影响，与亲代相比，对F1代的生长、成熟和生物累积有明显影响。这些发现表明金红石型二氧化钛纳米颗粒可能诱导毒性效应，强调了在毒性评估中幼体参数比成体参数更敏感。此外，该研究强调了迫切需要对纳米颗粒对陆地生物的长期毒性进行全面评估。开展多代研究将大大有助于更好地理解纳米颗粒对环境生物的生态毒性。
