大规模成年人群中软饮料消费与颈动脉粥样硬化的关联：TCLSIH队列研究。

Association between soft drink consumption and carotid atherosclerosis in a large-scale adult population: The TCLSIH cohort study.

作者信息

Meng Ge, Liu Tongfeng, Rayamajhi Sabina, Thapa Amrish, Zhang Shunming, Wang Xuena, Wu Hongmei, Gu Yeqing, Zhang Qing, Liu Li, Sun Shaomei, Wang Xing, Zhou Ming, Jia Qiyu, Song Kun, Fang Zhongze, Niu Kaijun

机构信息

Department of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, Tianjin, China; Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China; School of Public Health, Tianjin University of Traditional Chinese Medicine, Tianjin, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

出版信息

Nutr Metab Cardiovasc Dis. 2023 Nov;33(11):2209-2219. doi: 10.1016/j.numecd.2023.07.002. Epub 2023 Jul 19.

DOI:10.1016/j.numecd.2023.07.002

PMID:37586920

Abstract

BACKGROUND AND AIMS

Carotid atherosclerosis indicates an increased risk for cardiac-cerebral vascular disease. Given the pattern of consumption in China, sugar-sweetened beverage is the main type of soft drink consumed. As soft drinks contain a high amount of fructose, they may be a risk factor of carotid atherosclerosis. A prospective cohort study was conducted to investigate the association between soft drink consumption and the incidence of carotid atherosclerosis in a Chinese adult population.

METHODS AND RESULTS

A total of 3828 participants (men: 2007 and women: 1821) were included. Carotid atherosclerosis was measured by using ultrasonography and was defined by increased carotid intima-media thickness and/or carotid plaques. Soft drink consumption was assessed using a validated food frequency questionnaire. Cox proportional hazards regression analysis was used to assess the association of soft drink consumption categories with the incidence of carotid atherosclerosis. During a mean follow-up of 3.20 years, 1009 individuals of the 3828 eligible participants developed carotid atherosclerosis. After adjusting for potential confounding factors, we compared the higher levels to the lowest level of soft drink consumption in women, and we estimated the multivariable hazard ratios and 95% confidence intervals of incident carotid atherosclerosis to be 1.09 (0.80, 1.50), and 1.56 (1.14, 2.13) (P for trend <0.05). However, there was no significant association between soft drink consumption and the incidence of carotid atherosclerosis in men or total population.

CONCLUSION

The result indicated that soft drink consumption was associated with a higher incidence of carotid atherosclerosis in women.

TRIAL REGISTERED

UMIN Clinical Trials Registry.

TRIAL REGISTRATION NUMBER

UMIN000027174. TRIAL REGISTRATION WEBSITE: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000031137.

摘要

背景与目的

颈动脉粥样硬化表明心脑血管疾病风险增加。鉴于中国的消费模式，含糖饮料是主要消费的软饮料类型。由于软饮料含有大量果糖，它们可能是颈动脉粥样硬化的一个风险因素。进行了一项前瞻性队列研究，以调查中国成年人群中软饮料消费与颈动脉粥样硬化发病率之间的关联。

方法与结果

共纳入3828名参与者（男性：2007名，女性：1821名）。通过超声检查测量颈动脉粥样硬化，并通过颈动脉内膜中层厚度增加和/或颈动脉斑块来定义。使用经过验证的食物频率问卷评估软饮料消费情况。采用Cox比例风险回归分析来评估软饮料消费类别与颈动脉粥样硬化发病率之间的关联。在平均3.20年的随访期间，3828名符合条件的参与者中有1009人发生了颈动脉粥样硬化。在调整潜在混杂因素后，我们将女性软饮料消费的较高水平与最低水平进行了比较，估计发生颈动脉粥样硬化的多变量风险比和95%置信区间分别为1.09（0.80，1.50）和1.56（1.14，2.13）（趋势P<0.05）。然而，男性或总人群中软饮料消费与颈动脉粥样硬化发病率之间没有显著关联。