Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510632, China.
Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China.
Sci Bull (Beijing). 2023 Sep 30;68(18):2063-2076. doi: 10.1016/j.scib.2023.08.010. Epub 2023 Aug 5.
Despite significant advancements in our understanding of addiction at the neurobiological level, a highly effective extinction procedure for preventing relapse remains elusive. In this study, we report that bright light treatment (BLT) administered during cocaine withdrawal with extinction training prevents cocaine-driven reinstatement by acting through the thalamic-habenular pathway. We found that during cocaine withdrawal, the lateral habenula (LHb) was recruited, and inhibition of the LHb via BLT prevented cocaine-driven reinstatement. We also demonstrated that the effects of BLT were mediated by activating LHb-projecting neurons in the ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL) or by inhibiting postsynaptic LHb neurons. Furthermore, BLT was found to improve aversive emotional states induced by drug withdrawal. Our findings suggest that BLT administered during the cocaine withdrawal may be a promising strategy for achieving drug abstinence.
尽管我们在神经生物学水平上对成瘾有了更深入的了解，但仍缺乏一种非常有效的消除程序来预防复发。在这项研究中，我们报告说，在可卡因戒断期间进行强光治疗 (BLT) 并结合消除训练可通过丘脑-缰核途径预防可卡因驱动的复吸。我们发现，在可卡因戒断期间，外侧缰核 (LHb) 被募集，并且通过 BLT 抑制 LHb 可防止可卡因驱动的复吸。我们还表明，BLT 的作用是通过激活腹外侧膝状体核和中间膝状体小叶 (vLGN/IGL) 中的 LHb 投射神经元或抑制 LHb 神经元的突触后作用来介导的。此外，发现 BLT 可改善戒断引起的不良情绪状态。我们的研究结果表明，在可卡因戒断期间进行 BLT 可能是实现药物戒断的一种很有前途的策略。
