Department of Nuclear Medicine & Specialised PET Services, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4006, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.
J Nucl Cardiol. 2023 Dec;30(6):2676-2691. doi: 10.1007/s12350-023-03345-w. Epub 2023 Aug 16.
Cardiac metastases from neuroendocrine neoplasms (NENs) are being detected with increasing frequency, although the optimal imaging strategy remains unclear. We performed a single-center retrospective study to explore the role of somatostatin receptor positron emission tomography/computed tomography (SSTR PET/CT) and cardiac magnetic resonance imaging (CMR) in NEN cardiac metastases, determine the degree of concordance between the findings of these imaging modalities, and examine the advantages and disadvantages of each imaging technique. A secondary aim was to determine if cardiac metastases were associated with adverse cardiac events during peptide receptor radionuclide therapy (PRRT).
19 patients with NEN cardiac metastases were identified. A retrospective review of electronic medical records was performed, and if available SSTR PET/CT and CMR were blindly re-reviewed by imaging specialists, documenting the number and location of cardiac metastases. All 19 patients had SSTR PET/CT, and 10/19 patients had CMR. SSTR PET/CT identified more metastases than CMR. When identified on CMR, metastases were more accurately localized. 12/19 patients received PRRT, with no cardiac adverse effects.
SSTR PET/CT and CMR are complementary investigations in the imaging of NEN cardiac metastases. SSTR PET/CT appears more sensitive for lesion detection, and CMR offers better lesion characterization. Both investigations present useful information for the planning of treatment including PRRT, which was administered safely.
神经内分泌肿瘤（NEN）的心脏转移的检出率越来越高，但最佳的影像学策略仍不清楚。我们进行了一项单中心回顾性研究，以探讨生长抑素受体正电子发射断层扫描/计算机断层扫描（SSTR PET/CT）和心脏磁共振成像（CMR）在 NEN 心脏转移中的作用，确定这些影像学方法的结果的一致性程度，并检查每种影像学技术的优缺点。次要目的是确定心脏转移是否与肽受体放射性核素治疗（PRRT）期间的不良心脏事件有关。
确定了 19 例 NEN 心脏转移患者。对电子病历进行回顾性审查，如果有 SSTR PET/CT 和 CMR，则由影像学专家对其进行盲法重新审查，记录心脏转移的数量和位置。所有 19 例患者均进行了 SSTR PET/CT 检查，10/19 例患者进行了 CMR 检查。SSTR PET/CT 比 CMR 检测到更多的转移灶。在 CMR 上发现的转移灶更准确地定位。19 例患者中有 12 例接受了 PRRT，无心脏不良事件。
SSTR PET/CT 和 CMR 是 NEN 心脏转移的影像学检查的互补方法。SSTR PET/CT 对病灶检测更敏感，而 CMR 对病灶特征更有帮助。这两种检查都为治疗计划提供了有用的信息，包括安全进行的 PRRT。
