Epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose.
作者信息
Hoang An T, Corradin Olivia
机构信息
Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA.
出版信息
Neuropsychopharmacology. 2024 Jan;49(1):333-334. doi: 10.1038/s41386-023-01701-5.
Abstract
摘要
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本文引用的文献
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Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.对超过100万名受试者进行的多变量全基因组关联荟萃分析确定了多种物质使用障碍背后的基因座。
Nat Ment Health. 2023 Mar;1(3):210-223. doi: 10.1038/s44220-023-00034-y. Epub 2023 Mar 22.
2
Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose.特定病例的表观遗传改变的趋同确定了与阿片类药物过量相关的遗传脆弱性的汇合。
Mol Psychiatry. 2022 Apr;27(4):2158-2170. doi: 10.1038/s41380-022-01477-y. Epub 2022 Mar 17.
3
Genetics of substance use disorders in the era of big data.物质使用障碍的遗传学研究在大数据时代。
Nat Rev Genet. 2021 Nov;22(11):712-729. doi: 10.1038/s41576-021-00377-1. Epub 2021 Jul 1.
4
Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.阿片受体 μ 型 1 功能编码变异与阿片类药物使用障碍的关联：一项全基因组关联研究。
JAMA Psychiatry. 2020 Oct 1;77(10):1072-1080. doi: 10.1001/jamapsychiatry.2020.1206.
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