Department of Pharmacology, College of Medicine, Shaqra University, Shaqra, Saudi Arabia.
Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
Pak J Pharm Sci. 2023 May;36(3(Special)):953-961.
This study is carried out to assess the effects of rosuvastatin and simvastatin on blood vessels for possible vasorelaxant effect. The study is also translating the possible vasorelaxant effect in Wistar rats for a subsequent fall in systolic blood pressure. It is evident from the EC, that rosuvastatin is more effective on relaxing N.E induced contractions, while simvastatin is more effective on relaxing KCL induced contractions. Simvastatin is equipotent when compared to effects of amlodipine on KCl induced contractions in denuded aortae. Simvastatin produced significant right shift in test concentration 1.1× 10M with its respective EC -1.85logCaM as compared to its respective control EC -3logCaM. Rosuvastatin also produced significant right shift in the EC. In conclusion, it is stated that rosuvastatin and simvastatin relax the aortic strips preparations through inhibition of voltage gated calcium channels and inhibition of N.E induced contractions. Rosuvastatin and simvastatin have additive effects when used in the presence of a standard vaso-relaxant drug like amlodipine, which further confirms its additive effect on decreasing the systolic blood pressure of hypertensive rats (P<0.05).
本研究旨在评估瑞舒伐他汀和辛伐他汀对血管的影响，以探讨其可能的血管舒张作用。该研究还将在 Wistar 大鼠中进一步探讨可能的血管舒张作用与收缩压下降之间的关系。从 EC 可以明显看出，瑞舒伐他汀在松弛 N.E 诱导的收缩方面更有效，而辛伐他汀在松弛 KCL 诱导的收缩方面更有效。与 KCl 诱导的去内皮主动脉环中氨氯地平的作用相比，辛伐他汀的效果相当。与各自的对照 EC-3logCaM 相比，辛伐他汀在测试浓度 1.1×10M 时产生了显著的右移，其相应的 EC-1.85logCaM。瑞舒伐他汀也在 EC 中产生了显著的右移。总之，研究表明瑞舒伐他汀和辛伐他汀通过抑制电压门控钙通道和抑制 N.E 诱导的收缩来松弛主动脉条片。瑞舒伐他汀和辛伐他汀在与标准血管舒张药物（如氨氯地平）一起使用时具有相加作用，这进一步证实了它们在降低高血压大鼠的收缩压方面具有相加作用（P<0.05）。
