Donnington Grove Veterinary Group, Berkshire, UK.
Eclipse Veterinary Software Ltd, Essex, UK.
Equine Vet J. 2024 May;56(3):544-551. doi: 10.1111/evj.13988. Epub 2023 Aug 16.
Monitoring antibiotic usage is an important part of tackling antimicrobial resistance. The use of computerised records for monitoring has been previously described in the equine sector but there is currently no consensus on metrics used to report usage.
To document antibiotic use in equine practices in the United Kingdom over a 10-year period using commercially available practice management software.
Retrospective survey.
A custom antibiotic usage report was created using Eclipse® practice management software. Participating practices were given instructions on how to generate the usage report. Annual reports were requested for a 10-year period (2012-2021 inclusive). Each report provided sales of each class of antibiotic in total mg and in mg/kg, based on the number of equids treated (for any transaction) and their average weight. The defined daily dose for animals (DDDvet) and the DDD/1000 (used in people) were also calculated to correct for variation in dosage rates between antibiotics.
Fourteen practices submitted data for an annual maximum of 107 977 horses. Overall, median annual antibiotic usage was 54.25 mg/kg (range 45.34-60.27 mg/kg), 1.52 defined daily doses/animal/year (range 1.39-1.70) and 4.17 defined daily dose/1000 animals (range 3.82-4.66). Overall median highest priority critically important antimicrobial usage was 0.67 mg/kg (range 0.56-1.71), 0.12 defined daily doses/animal/year (range 0.10-0.14) and 0.33 defined daily dose/1000 animals (range 0.29-0.39).
The software relied on the accurate identification of antibiotic preparations. The calculation of DDDvet was complicated by the varying dose rates of antimicrobials used in equine practice.
A reliable technique to measure antibiotic usage is presented. Defined daily dosage calculations may be more helpful in equine practice due to the preponderance of potentiated sulphonamides usage. These data and methods may provide the basis for future clinical audits aiming to enhance antimicrobial stewardship.
监测抗生素使用情况是应对抗微生物药物耐药性的重要组成部分。以前在兽医领域已经描述过使用计算机记录进行监测，但目前对于用于报告使用情况的指标尚未达成共识。
使用商业上可用的实践管理软件，记录英国马科实践中 10 年来抗生素的使用情况。
回顾性调查。
使用 Eclipse®实践管理软件创建了一个自定义抗生素使用报告。向参与的实践提供了生成使用报告的说明。在 10 年内（包括 2012-2021 年）每年都请求报告。每个报告根据治疗的每头动物（任何交易）的数量及其平均体重，提供了每种抗生素的总毫克和每公斤毫克的销售量。还计算了动物的定义日剂量（DDDvet）和每 1000 只动物的 DDD（用于人），以纠正抗生素剂量率之间的差异。
14 家实践提交了数据，每年最多可治疗 107977 匹马。总体而言，抗生素年使用中位数为 54.25 毫克/公斤（范围为 45.34-60.27 毫克/公斤），1.52 动物/年定义日剂量（范围为 1.39-1.70）和 4.17 每 1000 只动物的定义日剂量（范围为 3.82-4.66）。总体中位数最高优先级关键重要抗菌药物使用量为 0.67 毫克/公斤（范围为 0.56-1.71），0.12 动物/年定义日剂量（范围为 0.10-0.14）和 0.33 每 1000 只动物的定义日剂量（范围为 0.29-0.39）。
该软件依赖于抗生素制剂的准确识别。由于在马科实践中使用的抗菌药物剂量率不同，因此计算 DDDvet 很复杂。
提出了一种可靠的测量抗生素使用量的技术。由于增效磺胺类药物的使用居多，因此在马科实践中使用定义日剂量计算可能更有帮助。这些数据和方法可能为旨在增强抗菌药物管理的未来临床审核提供基础。
