Molloy Cathleen, Choy Elizabeth H, Arechavala Rebecca J, Buennagel David, Nolty Anne, Spezzaferri Mitchell R, Sin Caleb, Rising Shant, Yu Jeremy, Al-Ezzi Abdulhakim, Kleinman Michael T, Kloner Robert A, Arakaki Xianghong
Cognition and Brain Integration Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.
Department of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.
Front Epidemiol. 2023;3. doi: 10.3389/fepid.2023.1168847. Epub 2023 May 26.
Resting heart rate (HR) and heart rate variability (HRV) have been linked with cognition in the general population and in older individuals. The knowledge of this aspect of heart-brain relationship is relatively absent in older individuals with early Alzheimer's disease (AD) pathology. This study explores relationships of the HR, HRV, and cognition in cognitively healthy individuals with pathological amyloid/tau ratio (CH-PATs) in cerebral spinal fluid (CSF) compared to those with normal ratio (CH-NATs).
We examined therelationshipsbetween1) resting HR and Mini-Mental State Examination (MMSE); 2) resting HR and brain processing during Stroop interference; and 3) resting vagally mediated HRV (vmHRV) and task switching performance.
Our studies showed that compared to CH-NATs, those CH-PATs with higher resting HR presented with lower MMSE, and less brain activation during interference processing. In addition, resting vmHRV was significantly correlated with task switching accuracy in CH-NATs, but not in CH-PATs.
Thesethreedifferenttestsindicatedysfunctionalheart-brainconnections in CH-PATs, suggesting a potential cardio-cerebral dysfunctional integration.
静息心率（HR）和心率变异性（HRV）与普通人群及老年人的认知功能有关。在患有早期阿尔茨海默病（AD）病理的老年人中，关于这种心脑关系方面的知识相对匮乏。本研究探讨了脑脊液（CSF）中病理性淀粉样蛋白/ tau比值的认知健康个体（CH - PATs）与正常比值个体（CH - NATs）相比，HR、HRV和认知之间的关系。
我们研究了1）静息心率与简易精神状态检查表（MMSE）之间的关系；2）静息心率与Stroop干扰期间的大脑处理过程之间的关系；3）静息迷走神经介导的心率变异性（vmHRV）与任务转换表现之间的关系。
我们的研究表明，与CH - NATs相比，静息心率较高的CH - PATs的MMSE得分较低，且在干扰处理期间大脑激活较少。此外，静息vmHRV与CH - NATs的任务转换准确性显著相关，但与CH - PATs无关。
这三项不同的测试表明CH - PATs的心脑连接功能失调，提示潜在的心脑功能失调整合。
