Zhang Xingwei, Lyu Xiaoyan
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Aug 11;16:2201-2209. doi: 10.2147/CCID.S417772. eCollection 2023.
Dermatomyositis (DM) is an autoimmune disorder characterized by proximal muscle weakness and distinct cutaneous features. Unfortunately, infection is a frequent and potentially life-threatening complication in patients with DM. Here, we present a case of pyomyositis in a patient with DM resulting from localized cellulitis. The patient also presented with subcutaneous calcification nodules and dermatomyositis-associated lipodermatosclerosis nodules. To our knowledge, there have been no reports of pyomyositis in patients with DM to date. Furthermore, we reviewed the infectious complications related to DM and polymyositis (PM). We found that idiopathic inflammatory myopathy (IIM) patients exhibit a considerable infection-related mortality rate, ranging from 4.3% to 7.2%. In IIM, infections were identified as the primary cause of mortality in a substantial proportion of cases, accounting for 22.0-83.3% of deaths. These findings have implications for the importance of identifying and managing infections in IIM patients and suggest the need for further research into infection-related complications in these patients.
皮肌炎（DM）是一种自身免疫性疾病，其特征为近端肌无力和独特的皮肤表现。不幸的是，感染是DM患者常见且可能危及生命的并发症。在此，我们报告一例DM患者因局部蜂窝织炎导致的脓性肌炎病例。该患者还出现了皮下钙化结节和皮肌炎相关的脂膜炎性硬化结节。据我们所知，迄今为止尚无DM患者发生脓性肌炎的报道。此外，我们回顾了与DM和多发性肌炎（PM）相关的感染性并发症。我们发现，特发性炎性肌病（IIM）患者的感染相关死亡率相当高，在4.3%至7.2%之间。在IIM中，感染在相当一部分病例中被确定为主要死因，占死亡病例的22.0 - 83.3%。这些发现凸显了识别和管理IIM患者感染的重要性，并表明有必要对这些患者的感染相关并发症进行进一步研究。
