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Histone demethylase Kdm5c regulates osteogenesis and bone formation via PI3K/Akt/HIF1α and Wnt/β-catenin signaling pathways.

作者信息

Li Ying, Ding Lingli, Zhang Yage, Zhou Bingyu, Wai Man Gene Chi, Wang Min, Li Jinglan, Liu Yamei, Lin Weiping, Wang Haibin, Lin Sien, Xu Liangliang

机构信息

Key Laboratory of Orthopaedics & Traumatology, Lingnan Medical Research Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510000, China.

Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR 999077, China.

出版信息

Genes Dis. 2023 Apr 4;11(1):64-66. doi: 10.1016/j.gendis.2023.02.041. eCollection 2024 Jan.

DOI:10.1016/j.gendis.2023.02.041
PMID:37588198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10425781/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3978/10425781/36800ffb354f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3978/10425781/36800ffb354f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3978/10425781/36800ffb354f/gr1.jpg

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J Orthop Translat. 2020 Dec 10;27:25-32. doi: 10.1016/j.jot.2020.10.009. eCollection 2021 Mar.
2
Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells.通过用成骨诱导培养基预处理获得的表观遗传记忆可改善间充质干细胞的成骨能力和其他特性。
Sci Rep. 2015 Jun 8;5:11056. doi: 10.1038/srep11056.
3
Delayed union and nonunions: epidemiology, clinical issues, and financial aspects.
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SGMS1 facilitates osteogenic differentiation of MSCs and strengthens osteogenesis-angiogenesis coupling by modulating Cer/PP2A/Akt pathway.SGMS1通过调节神经酰胺/蛋白磷酸酶2A/蛋白激酶B途径促进间充质干细胞的成骨分化并加强成骨-血管生成耦合。
iScience. 2024 Mar 5;27(4):109358. doi: 10.1016/j.isci.2024.109358. eCollection 2024 Apr 19.
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