射血分数保留的心力衰竭的当前认知
Current Knowledge of Heart Failure with Preserved Ejection Fraction.
作者信息
PhD Leonida Gherasim Md
机构信息
Professor, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania Cardiology, University Hospital of Bucharest, Romania.
出版信息
Maedica (Bucur). 2023 Jun;18(2):323-332. doi: 10.26574/maedica.2023.18.2.323.
Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure (HF) - predominantly in the elderly population - and the most difficult to treat. The diagnosis is based, apart from clinical data, on data provided by imaging and biochemical evaluation: left ventricular (LV) diastolic dysfunction, EF ≥50% and increase of natriuretic peptide (NP). Several phenotypes of HFpEF have been identified based on etiological and pathophysiological data. Defining the phenotypes has allowed a wider knowledge of specific pathogenic mechanisms and conducting therapeutic studies with pharmacological and non-pharmacological agents . but with uncertain results. The diagnosis is based, apart from clinical data, on data provided by imaging and biochemical evaluation: left ventricular (LV) diastolic dysfunction, EF ≥50% and increase of natriuretic peptide (NP). Several phenotypes of HFpEF have been identified based on etiological and pathophysiological data. Defining the phenotypes has allowed a wider knowledge of specific pathogenic mechanisms and conducting therapeutic studies with pharmacological and non-pharmacological agents . but with uncertain results.
射血分数保留的心力衰竭（HFpEF）是最常见的心力衰竭类型——主要见于老年人群——且最难治疗。除临床数据外，诊断还基于影像学和生化评估所提供的数据：左心室（LV）舒张功能障碍、射血分数（EF）≥50%以及利钠肽（NP）升高。基于病因学和病理生理学数据，已确定了HFpEF的几种表型。对这些表型的定义有助于更广泛地了解特定的致病机制，并开展使用药物和非药物制剂的治疗研究，但结果尚不确定。除临床数据外，诊断还基于影像学和生化评估所提供的数据：左心室（LV）舒张功能障碍、射血分数（EF）≥50%以及利钠肽（NP）升高。基于病因学和病理生理学数据，已确定了HFpEF的几种表型。对这些表型的定义有助于更广泛地了解特定的致病机制，并开展使用药物和非药物制剂的治疗研究，但结果尚不确定。
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