PhD Leonida Gherasim Md
Professor, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania Cardiology, University Hospital of Bucharest, Romania.
Maedica (Bucur). 2023 Jun;18(2):323-332. doi: 10.26574/maedica.2023.18.2.323.
Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure (HF) - predominantly in the elderly population - and the most difficult to treat. The diagnosis is based, apart from clinical data, on data provided by imaging and biochemical evaluation: left ventricular (LV) diastolic dysfunction, EF ≥50% and increase of natriuretic peptide (NP). Several phenotypes of HFpEF have been identified based on etiological and pathophysiological data. Defining the phenotypes has allowed a wider knowledge of specific pathogenic mechanisms and conducting therapeutic studies with pharmacological and non-pharmacological agents . but with uncertain results. The diagnosis is based, apart from clinical data, on data provided by imaging and biochemical evaluation: left ventricular (LV) diastolic dysfunction, EF ≥50% and increase of natriuretic peptide (NP). Several phenotypes of HFpEF have been identified based on etiological and pathophysiological data. Defining the phenotypes has allowed a wider knowledge of specific pathogenic mechanisms and conducting therapeutic studies with pharmacological and non-pharmacological agents . but with uncertain results.
射血分数保留的心力衰竭（HFpEF）是最常见的心力衰竭类型——主要见于老年人群——且最难治疗。除临床数据外，诊断还基于影像学和生化评估所提供的数据：左心室（LV）舒张功能障碍、射血分数（EF）≥50%以及利钠肽（NP）升高。基于病因学和病理生理学数据，已确定了HFpEF的几种表型。对这些表型的定义有助于更广泛地了解特定的致病机制，并开展使用药物和非药物制剂的治疗研究，但结果尚不确定。除临床数据外，诊断还基于影像学和生化评估所提供的数据：左心室（LV）舒张功能障碍、射血分数（EF）≥50%以及利钠肽（NP）升高。基于病因学和病理生理学数据，已确定了HFpEF的几种表型。对这些表型的定义有助于更广泛地了解特定的致病机制，并开展使用药物和非药物制剂的治疗研究，但结果尚不确定。
