Wu Qian, Huang Yuanyuan, Kong Xiangya, Jia Ben, Lu Xiaoting, Chen Yunqin, Huang Zechi, Li Yuan-Yuan, Dai Wentao
NHC Key Laboratory of Reproduction Regulation & Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Fudan University, No. 779, Old Hu Min Road, Shanghai, 200237 China.
Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China.
Phenomics. 2023 May 16;3(4):350-359. doi: 10.1007/s43657-023-00099-w. eCollection 2023 Aug.
To help researchers in the field of biology, medicine, chemistry, and materials science to use lipidomic data conveniently, there is an urgent need to develop a platform that provides a systematic knowledgebase of human lipid metabolism and lipidome-centric omics analysis tools. DBLiPro is a user-friendly webserver allowing for access to human metabolism-related lipids and proteins knowledge database and an interactive bioinformatics integrative analysis workflow for lipidomics, transcriptomics, and proteomics data. In DBLiPro, there are 3109 lipid-associated proteins (LAPs) and 2098 lipid metabolites in the knowledge base section, which were obtained from Uniprot, Kyoto Encyclopedia of Genes and Genomes (KEGG) and were further annotated by information from other public resources in the knowledge base section, such as RaftProt and PubChem. DBLiPro offers a step-by-step interactive analysis workflow for lipidomics, transcriptomics, proteomics, and their integrating multi-omics analysis focusing on the human lipid metabolism. In summary, DBLiPro is capable of helping users discover key molecules (lipids and proteins) in human lipid metabolism and investigate lipid-protein functions underlying mechanisms based on their own omics data. The DBLiPro is freely available at http://lipid.cloudna.cn/home.
为帮助生物学、医学、化学和材料科学领域的研究人员方便地使用脂质组学数据，迫切需要开发一个平台，提供人类脂质代谢的系统知识库以及以脂质组为中心的组学分析工具。DBLiPro是一个用户友好的网络服务器，可访问与人类代谢相关的脂质和蛋白质知识库，以及用于脂质组学、转录组学和蛋白质组学数据的交互式生物信息学综合分析工作流程。在DBLiPro中，知识库部分有3109个脂质相关蛋白（LAP）和2098种脂质代谢物，这些数据来自Uniprot、京都基因与基因组百科全书（KEGG），并在知识库部分通过来自其他公共资源（如RaftProt和PubChem）的信息进行了进一步注释。DBLiPro为脂质组学、转录组学、蛋白质组学及其整合多组学分析提供了一个逐步的交互式分析工作流程，重点是人类脂质代谢。总之，DBLiPro能够帮助用户发现人类脂质代谢中的关键分子（脂质和蛋白质），并根据自己的组学数据研究脂质-蛋白质功能的潜在机制。可通过http://lipid.cloudna.cn/home免费访问DBLiPro。
