Wang Siyuan, Jiang Huan, Hu Moran, Gong Yingyun, Zhou Hongwen
Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.
Heliyon. 2024 Nov 29;10(23):e40810. doi: 10.1016/j.heliyon.2024.e40810. eCollection 2024 Dec 15.
Sphingomyelin is an important member of the sphingolipid family and was first reported more than a century ago. It has been demonstrated that sphingomyelin plays a crucial role in compositing cell membranes and signaling pathways. Despite extensive functional studies on the sphingolipid metabolism pathway genes, one intriguing question remains: how does the emergence of these genes during evolution correlate with the acquisition of new functions in different species? By employing an evolutionary conservation analysis, the sequence of occurrence of biological processes during evolutionary history can be elucidated. Here we summarize and analyze the conservation status of the genes involved in sphingomyelin metabolism.
鞘磷脂是鞘脂家族的重要成员，早在一个多世纪前就有报道。已证明鞘磷脂在细胞膜组成和信号通路中起关键作用。尽管对鞘脂代谢途径基因进行了广泛的功能研究，但仍有一个有趣的问题：这些基因在进化过程中的出现与不同物种新功能的获得有何关联？通过进行进化保守性分析，可以阐明进化历史中生物过程出现的顺序。在此，我们总结并分析参与鞘磷脂代谢的基因的保守状态。
