Shaver W A, Bhatt H, Combes B
Hepatology. 1986 Sep-Oct;6(5):859-63. doi: 10.1002/hep.1840060509.
Low values for serum alkaline phosphatase activity were observed early in the course of two patients with Wilson's disease presenting with the combination of severe liver disease and Coombs' negative acute hemolytic anemia. A review of other cases of Wilson's disease revealed that 11 of 12 patients presenting with hemolytic anemia had values for serum alkaline phosphatase less than their respective sex- and age-adjusted mean values; in eight, serum alkaline phosphatase activity was less than the lower value for the normal range of the test. Low values for serum alkaline phosphatase were much less common in Wilson's disease patients with more chronic forms of presentation. Copper added in high concentration to serum in vitro did not have an important effect on serum alkaline phosphatase activity. The mechanism responsible for the decrease in serum alkaline phosphatase activity in patients is uncertain.
在两名患有威尔逊氏病的患者病程早期，观察到血清碱性磷酸酶活性值较低，这两名患者同时伴有严重肝病和库姆斯试验阴性的急性溶血性贫血。对威尔逊氏病其他病例的回顾显示，12例出现溶血性贫血的患者中有11例血清碱性磷酸酶值低于其各自经性别和年龄校正的平均值；其中8例血清碱性磷酸酶活性低于该检测正常范围的下限值。血清碱性磷酸酶值较低在呈现更慢性形式的威尔逊氏病患者中不太常见。体外向血清中添加高浓度铜对血清碱性磷酸酶活性没有重要影响。导致患者血清碱性磷酸酶活性降低的机制尚不确定。
