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铁、锌、铜、镉、汞与骨组织。

Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue.

机构信息

Chair and Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, Żołnierska 54, 70-210 Szczecin, Poland.

Department of Biology and Medical Parasitology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.

出版信息

Int J Environ Res Public Health. 2023 Jan 26;20(3):2197. doi: 10.3390/ijerph20032197.


DOI:10.3390/ijerph20032197
PMID:36767564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9915283/
Abstract

The paper presents the current understanding on the effects of five metals on bone tissue, namely iron, zinc, copper, cadmium, and mercury. Iron, zinc, and copper contribute significantly to human and animal metabolism when present in sufficient amounts, but their excess or shortage increases the risk of developing bone disorders. In contrast, cadmium and mercury serve no physiological purpose and their long-term accumulation damages the osteoarticular system. We discuss the methods of action and interactions between the discussed elements as well as the concentrations of each element in distinct bone structures.

摘要

本文介绍了目前人们对五种金属(铁、锌、铜、镉和汞)对骨骼组织影响的认识。在适量存在的情况下,铁、锌和铜对人体和动物的新陈代谢有重要贡献,但过量或缺乏会增加骨骼疾病的风险。相比之下,镉和汞没有生理作用,它们的长期积累会损害骨-关节系统。我们讨论了所讨论元素的作用方式和相互作用,以及每个元素在不同骨骼结构中的浓度。

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本文引用的文献

[1]
Effects of inorganic mercury exposure in the alveolar bone of rats: an approach of qualitative and morphological aspects.

PeerJ. 2022

[2]
Copper as Dietary Supplement for Bone Metabolism: A Review.

Nutrients. 2021-6-29

[3]
Natural incorporation of mercury in bone.

J Trace Elem Med Biol. 2021-9

[4]
The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue.

Biomolecules. 2021-3-28

[5]
Influence of Cu on Osteoclast Formation and Activity In Vitro.

Int J Mol Sci. 2021-2-28

[6]
The role of TGF-β1/Smad3 signaling pathway and oxidative stress in the inhibition of osteoblast mineralization by copper chloride.

Environ Toxicol Pharmacol. 2021-5

[7]
Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia.

Adv Sci (Weinh). 2020-8-4

[8]
The Role of Fe, Zn, and Cu in Pregnancy.

Biomolecules. 2020-8-12

[9]
The Effects of Cadmium Toxicity.

Int J Environ Res Public Health. 2020-5-26

[10]
Zinc as a Therapeutic Agent in Bone Regeneration.

Materials (Basel). 2020-5-12

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