Wood J R, Czaja A J, Beaver S J, Hall S, Ginsburg W W, Kaufman D K, Markowitz H
Hepatology. 1986 Sep-Oct;6(5):976-80. doi: 10.1002/hep.1840060528.
To assess the frequency and significance of immunoglobulin G antibody to double-stranded DNA in chronic active hepatitis, 99 patients with severe disease were tested for the antibody by an enzyme-linked immunosorbent assay of established sensitivity and specificity. Antibody was detected in 56 patients (57%) and occurred with similar frequency in patients with autoimmune (64%), idiopathic (46%) and type B (43%) disease. The mean serum level of antibody was higher in autoimmune disease but it was not significantly different from that in the other diagnostic categories. Patients with and without the antibody could not be distinguished by clinical, laboratory or histologic findings. Responses to corticosteroid therapy and mortality were unrelated to antibody status. In five patients, the antibody disappeared after corticosteroid treatment and induction of histologic remission. We conclude that immunoglobulin G antibody to double-stranded DNA is frequently present in patients with severe chronic active hepatitis. Patients with autoimmune disease may have higher antibody levels than others, but the presence of antibody does not connote a disease of specific etiology, unique presentation or different behavior. The prevalence of the finding and its disappearance after corticosteroid therapy suggest that it is a nonspecific manifestation of inflammatory activity.
为评估慢性活动性肝炎患者中抗双链DNA免疫球蛋白G抗体的出现频率及意义，采用具有既定敏感性和特异性的酶联免疫吸附试验，对99例重症患者进行了该抗体检测。56例患者（57%）检测到抗体，自身免疫性疾病（64%）、特发性疾病（46%）和B型疾病（43%）患者中抗体出现频率相似。自身免疫性疾病患者的抗体平均血清水平较高，但与其他诊断类型患者相比无显著差异。有无抗体的患者在临床、实验室或组织学检查结果上无法区分。对皮质类固醇治疗的反应及死亡率与抗体状态无关。5例患者在皮质类固醇治疗及组织学缓解诱导后抗体消失。我们得出结论，重症慢性活动性肝炎患者中经常存在抗双链DNA免疫球蛋白G抗体。自身免疫性疾病患者的抗体水平可能高于其他患者，但抗体的存在并不意味着特定病因、独特表现或不同行为的疾病。该发现的普遍性及其在皮质类固醇治疗后消失表明它是炎症活动的非特异性表现。
