Czaja Albert J, Shums Zakera, Binder Walter L, Lewis Stephen J, Nelson Vicki J, Norman Gary L
Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Dig Dis Sci. 2003 Aug;48(8):1658-64. doi: 10.1023/a:1024748714580.
Our aims were to determine the frequency and prognostic implications of antibodies to chromatin in autoimmune hepatitis. Three hundred seventy-one serum samples from 172 patients were tested by enzyme-linked immunosorbent assay. Sixty-seven patients (39%) had antibodies to chromatin. Percent positivity was greater in men than women (58% vs 34%, P = 0.008), and seropositivity was associated with higher serum levels of gamma-globulin and immunoglobulin G. Antibodies to chromatin disappeared in 25 of 60 patients who were tested successively (42%), and they were more common in samples obtained during active than inactive disease (32% vs 19%, P = 0.01). Relapse after drug withdrawal occurred more often in seropositive patients (91% vs 66%, P = 0.002). We conclude that antibodies to chromatin occur commonly in autoimmune hepatitis, and they are associated with disease activity. Percent positivity is greater in men than women, and seropositivity identifies individuals who commonly relapse after drug withdrawal.
我们的目的是确定自身免疫性肝炎中抗染色质抗体的频率及其预后意义。采用酶联免疫吸附试验检测了172例患者的371份血清样本。67例患者（39%）存在抗染色质抗体。男性的阳性率高于女性（58%对34%，P = 0.008），血清阳性与较高的血清γ-球蛋白和免疫球蛋白G水平相关。60例接受连续检测的患者中有25例（42%）抗染色质抗体消失，且这些抗体在疾病活动期采集的样本中比非活动期更常见（32%对19%，P = 0.01）。血清阳性患者停药后复发更为常见（91%对66%，P = 0.002）。我们得出结论，抗染色质抗体在自身免疫性肝炎中常见，且与疾病活动相关。男性的阳性率高于女性，血清阳性可识别出停药后常见复发的个体。
