Chen Chun-Chao, Lin Hsuan-Wen, Feng Kuan-Lin, Tseng Der-Wan, de Belle J Steven, Chiang Ann-Shyn
Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
Cell Rep. 2023 Aug 29;42(8):112974. doi: 10.1016/j.celrep.2023.112974. Epub 2023 Aug 16.
Long-term memory (LTM) requires learning-induced synthesis of new proteins allocated to specific neurons and synapses in a neural circuit. Not all learned information, however, becomes permanent memory. How the brain gates relevant information into LTM remains unclear. In Drosophila adults, weak learning after a single training session in an olfactory aversive task typically does not induce protein-synthesis-dependent LTM. Instead, strong learning after multiple spaced training sessions is required. Here, we report that pre-synaptic active-zone protein synthesis and cholinergic signaling from the early α/β subset of mushroom body (MB) neurons produce a downstream inhibitory effect on LTM formation. When we eliminated inhibitory signaling from these neurons, weak learning was then sufficient to form LTM. This bidirectional circuit mechanism modulates the transition between distinct memory phase functions in different subpopulations of MB neurons in the olfactory memory circuit.
长期记忆（LTM）需要学习诱导合成新的蛋白质，并将其分配到神经回路中的特定神经元和突触。然而，并非所有学到的信息都会成为永久记忆。大脑如何筛选相关信息进入长期记忆仍不清楚。在成年果蝇中，在嗅觉厌恶任务中单次训练后的弱学习通常不会诱导蛋白质合成依赖性长期记忆。相反，需要在多次间隔训练后进行强学习。在这里，我们报告突触前活性区蛋白质合成以及来自蘑菇体（MB）神经元早期α/β亚群的胆碱能信号对长期记忆形成产生下游抑制作用。当我们消除这些神经元的抑制信号时，弱学习就足以形成长期记忆。这种双向回路机制调节嗅觉记忆回路中不同亚群的蘑菇体神经元在不同记忆阶段功能之间的转换。
