Hammar S, Bockus D, Remington F, Bartha M
Hum Pathol. 1986 Sep;17(9):894-905. doi: 10.1016/s0046-8177(86)80639-6.
Ultrastructural and/or immunohistochemical analysis of approximately 500 specimens revealed widespread distribution of Langerhans cells in pathologic specimens. More than half of the tissue specimens were from patients with a variety of pulmonary diseases. In all specimens in which Langerhans cells were identified ultrastructurally, they were also identified by an immunoperoxidase technique for the visualization of S-100 protein; the latter technique also revealed the dendritic nature of these cells. Langerhans cells were present in 80 to 93 per cent of 66 pulmonary adenocarcinomas and 17 per cent of squamous cell lung cancers; they were not observed in neuroendocrine lung carcinomas or mesotheliomas. They were also observed in benign inflammatory conditions of the lung of several types and in a variety of other malignant neoplasms and disease processes. The Langerhans cells in these tissues varied from few to many. They were most numerous in bronchioloalveolar cell carcinoma, sometimes appearing almost as frequently as tumor cells, and rare in some benign pulmonary conditions and other tumors. The function of Langerhans cells in these conditions is unknown, but they may have an immunologic function, such as antigen processing and presentation to T lymphocytes.
对约500份标本进行的超微结构和/或免疫组织化学分析显示，病理标本中朗格汉斯细胞广泛分布。超过半数的组织标本来自患有各种肺部疾病的患者。在所有经超微结构鉴定出朗格汉斯细胞的标本中，通过免疫过氧化物酶技术检测S-100蛋白也鉴定出了这些细胞；后一种技术还揭示了这些细胞的树突状性质。在66例肺腺癌中有80%至93%存在朗格汉斯细胞，在肺鳞状细胞癌中有17%存在朗格汉斯细胞；在肺神经内分泌癌或间皮瘤中未观察到朗格汉斯细胞。在几种类型的肺部良性炎症以及各种其他恶性肿瘤和疾病过程中也观察到了朗格汉斯细胞。这些组织中的朗格汉斯细胞数量不一，从少数到多数不等。在细支气管肺泡癌中数量最多，有时出现频率几乎与肿瘤细胞相同，而在一些良性肺部疾病和其他肿瘤中则很少见。这些情况下朗格汉斯细胞的功能尚不清楚，但它们可能具有免疫功能，如抗原处理和呈递给T淋巴细胞。
