Carey F A, Wallace W A, Fergusson R J, Kerr K M, Lamb D
Department of Pathology, University of Edinburgh.
Thorax. 1992 Dec;47(12):1041-3. doi: 10.1136/thx.47.12.1041.
A distinctive cytologically atypical lesion has been found in patients with primary adenocarcinoma of the lung. The aim of this study was to characterise the lesion and assess its role in tumour pathogenesis.
Lung parenchyma from 175 consecutive resection specimens for primary pulmonary adenocarcinoma were examined. Foci of atypical hyperplasia were identified. Cell proliferation state and expression of S100 and carcinoembryonic antigens were evaluated by immunohistochemistry. Clinical data on cigarette smoking and occupational exposure to carcinogens were abstracted from inpatient case notes.
Ten cases (5.7%) with these distinctive cytologically atypical lesions were identified. The lesions showed immunohistochemical evidence of increased cell proliferation and focal carcinoembryonic antigen expression. The associated adenocarcinomas were of peripheral (parenchymal) type. There was an association with cigarette smoking and two of the 10 patients had synchronous carcinomas elsewhere in the lung.
The clinical and pathological associations of these lesions suggest that they may be important in the histogenesis of primary pulmonary adenocarcinoma.
在原发性肺腺癌患者中发现了一种具有独特细胞学非典型性的病变。本研究的目的是对该病变进行特征描述并评估其在肿瘤发病机制中的作用。
对175例连续的原发性肺腺癌切除标本的肺实质进行检查。识别出非典型增生灶。通过免疫组织化学评估细胞增殖状态以及S100和癌胚抗原的表达。从住院病历中提取吸烟和职业致癌物暴露的临床数据。
识别出10例（5.7%）具有这些独特细胞学非典型性病变的病例。这些病变显示出细胞增殖增加和局灶性癌胚抗原表达的免疫组织化学证据。相关的腺癌为外周型（实质型）。与吸烟有关，10例患者中有2例在肺部其他部位同时存在癌。
这些病变的临床和病理关联表明它们可能在原发性肺腺癌的组织发生中起重要作用。
