Department of Otolaryngology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich.
Department of Otolaryngology, Guy's and St Thomas' NHS Foundation Trust, London.
Otol Neurotol. 2023 Oct 1;44(9):925-930. doi: 10.1097/MAO.0000000000003984. Epub 2023 Aug 14.
To identify key risk factors for the development of bilateral Ménière's disease.
Observational study.
Four NHS Trusts and four independent hospitals or clinics, within three distinct urban and rural regions within the United Kingdom (Norfolk, Leicestershire, and London).
Patients with Ménière's disease were identified at ENT or audiovestibular medicine secondary/tertiary care and specialist private clinics. A range of patient-reported data, questionnaire data, and clinical data (audiometric, radiological, and specialist balance testing data) was inputted into a bespoke database. A logistic regression model was used to identify potential risk factors for bilateral Ménière's disease compared with unilateral Ménière's disease.
A total of 411 participants were recruited into this study, 263 from NHS Trusts and 148 from independent hospitals or clinics. In our cohort of patients, 22% of individuals were identified as having bilateral Ménière's disease. Two statistically significant independent variables were identified as risk factors for the development of bilateral Ménière's disease: the presence of psoriasis and a history of ear infections.
Psoriasis and a history of ear infection have been identified as key risk factors for the development of bilateral Ménière's disease. It is anticipated that further work based on this finding will allow a better understanding of the underlying pathophysiological mechanisms that predispose to the development of Ménière's disease symptoms.
确定双侧梅尼埃病发展的关键风险因素。
观察性研究。
英国三个不同城乡地区（诺福克、莱斯特郡和伦敦）的四家 NHS 信托机构和四家独立医院或诊所。
在耳鼻喉科或听觉医学二级/三级护理和专门的私人诊所发现梅尼埃病患者。将一系列患者报告数据、问卷调查数据和临床数据（听力、影像学和专门的平衡测试数据）输入到定制数据库中。使用逻辑回归模型来确定双侧梅尼埃病与单侧梅尼埃病相比的潜在风险因素。
共有 411 名参与者参与了这项研究，其中 263 名来自 NHS 信托机构，148 名来自独立医院或诊所。在我们的患者队列中，有 22%的人被确定为双侧梅尼埃病。两个具有统计学意义的独立变量被确定为双侧梅尼埃病发展的风险因素：银屑病的存在和耳部感染史。
银屑病和耳部感染史已被确定为双侧梅尼埃病发展的关键风险因素。预计基于这一发现的进一步工作将有助于更好地了解导致梅尼埃病症状发展的潜在病理生理机制。
