Department of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
School of Nursing, Ningxia Medical University, Yinchuan, Ningxia, China.
Metab Syndr Relat Disord. 2023 Aug;21(6):306-313. doi: 10.1089/met.2022.0100.
Various diseases are associated with obesity and metabolism. We sought to investigate the risk of cardiovascular disease (CVD) in diverse metabolic obesity phenotypes. A prospective observational study of 1517 participants ≥25 years of age without CVD at baseline was conducted. Participants were categorized into four groups based on the condition of central obesity and metabolic health status: metabolically healthy normal weight, metabolically healthy obesity (MHO), metabolically unhealthy normal weight, and metabolically unhealthy obese (MUO). A multivariate Cox regression analysis was used to analyze the relationship between different obesity phenotypes and CVD. During 14830.49 person-years of follow-up, there were 244 incident cases of CVD. Of the 1517 participants, 72 (4.75%) and 812 (53.53%) were classified as having MHO and MUO, respectively. MHO and MUO had a tendency toward a higher risk of CVD [adjusted hazard ratios (HRs) = 1.49, 95% confidence interval (CI): 1.11-2.02 and HR = 1.25, 95% CI: 1.00-1.55, respectively] based on the waist circumference criterion. MHO and MUO can increase the risk of CVD.
各种疾病都与肥胖和新陈代谢有关。我们试图研究不同代谢肥胖表型中心血管疾病 (CVD) 的风险。对 1517 名年龄≥25 岁且基线时无 CVD 的参与者进行了一项前瞻性观察研究。根据中心性肥胖和代谢健康状况，将参与者分为以下四组：代谢健康正常体重、代谢健康肥胖 (MHO)、代谢不健康正常体重和代谢不健康肥胖 (MUO)。使用多变量 Cox 回归分析来分析不同肥胖表型与 CVD 之间的关系。在 14830.49 人年的随访期间，发生了 244 例 CVD 事件。在 1517 名参与者中，72 名（4.75%）和 812 名（53.53%）分别归类为患有 MHO 和 MUO。根据腰围标准，MHO 和 MUO 发生 CVD 的风险呈上升趋势[校正后的危险比（HRs）=1.49，95%置信区间（CI）：1.11-2.02 和 HR=1.25，95% CI：1.00-1.55]。MHO 和 MUO 可增加 CVD 的风险。
