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丹麦市售儿童化妆品中的香料过敏原。

Fragrance allergens in cosmetic products marketed for children in Denmark.

机构信息

The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology, Copenhagen University Hospital Herlev-Gentofte, Gentofte Hospital, Hellerup, Denmark.

Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen N, Denmark.

出版信息

Contact Dermatitis. 2023 Nov;89(5):374-381. doi: 10.1111/cod.14397. Epub 2023 Aug 17.

Abstract

BACKGROUND

Fragrances are among the most common contact allergens in children. Cosmetic products are the most frequent source of skin exposure.

OBJECTIVE

To investigate exposure to fragrance allergens among Danish children, based on a sample of 1179 cosmetic products marketed for children.

METHODS

Information regarding cosmetic products marketed to children was obtained using a non-profit smartphone application registry, with data from December 2015 to November 2022.

RESULTS

The number of validated products was 26  537, of which 1349 marketed for children. After elimination of duplicates, 1179 (4.4%) individual products remained. The majority 53.8% (634/1179) of the products were fragranced. The highest frequency of declared fragrances was found in 'Facial care'-products: 93.0% (80/86), of which 97.7% were lip balms. The highest number of labelled fragrances in one single product (n = 16) was found in a baby perfume. Fragrance mix I (FMI) or II (FMII) allergens were found in 25.3% (298/1179) of the products. Limonene and linalool were the two most frequently labelled fragrance allergens.

CONCLUSION

Children can be exposed to a vast number of fragrance allergens from scented cosmetic products. Allergens from FM I and FMII are widely used in cosmetic products marketed to children. Patch testing with FMI and FMII remains relevant in children.

摘要

背景

香料是儿童最常见的接触过敏原之一。化妆品是皮肤接触的最常见来源。

目的

基于针对儿童的 1179 种市售化妆品样本,调查丹麦儿童接触香料过敏原的情况。

方法

使用非营利性智能手机应用程序注册获取有关市售儿童化妆品的信息,数据来自 2015 年 12 月至 2022 年 11 月。

结果

验证产品的数量为 26537 种,其中 1349 种为儿童专用。消除重复项后,剩余 1179 种(4.4%)个别产品。53.8%(634/1179)的产品为香薰。在“面部护理”产品中发现宣称有香味的产品频率最高:93.0%(80/86),其中 97.7%是护唇膏。在一种婴儿香水中发现了标签上数量最多的 16 种香料。在 1179 种产品中发现有 25.3%(298/1179)含有香料混合物 I(FMI)或 II(FMII)过敏原。柠檬烯和芳樟醇是两种最常被标记的香料过敏原。

结论

儿童可能会接触到大量含香料的化妆品中的过敏原。FM I 和 FMII 中的过敏原广泛用于市售儿童化妆品。FM I 和 FMII 的斑贴试验在儿童中仍然具有相关性。

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