MindScope Program, Allen Institute, Seattle, Washington 98109.
Department of Computer Science, University of Washington, Seattle, Washington 98195-2350.
eNeuro. 2023 Sep 15;10(9). doi: 10.1523/ENEURO.0051-23.2023. Print 2023 Sep.
Rapid saccadic eye movements are used by animals to sample different parts of the visual scene. Previous work has investigated neural correlates of these saccades in visual cortical areas such as V1; however, how saccade-responsive neurons are distributed across visual areas, cell types, and cortical layers has remained unknown. Through analyzing 818 1 h experimental sessions from the Allen Brain Observatory, we present a large-scale analysis of saccadic behaviors in head-fixed mice and their neural correlates. We find that saccade-responsive neurons are present across visual cortex, but their distribution varies considerably by transgenically defined cell type, cortical area, and cortical layer. We also find that saccade-responsive neurons do not exhibit distinct visual response properties from the broader neural population, suggesting that the saccadic responses of these neurons are likely not predominantly visually driven. These results provide insight into the roles played by different cell types within a broader, distributed network of sensory and motor interactions.
快速眼球运动是动物用来采样视觉场景不同部分的方法。以前的工作已经研究了 V1 等视觉皮层区域中这些眼球运动的神经相关性；然而，眼球运动反应神经元在视觉区域、细胞类型和皮层层中的分布情况仍然未知。通过分析艾伦脑观测站的 818 个 1 小时实验会议，我们对头部固定小鼠的眼球运动行为及其神经相关性进行了大规模分析。我们发现，眼球运动反应神经元存在于整个视觉皮层中，但它们的分布因转基因定义的细胞类型、皮层区域和皮层层而有很大差异。我们还发现，眼球运动反应神经元的视觉反应特性与更广泛的神经元群体没有明显区别，这表明这些神经元的眼球运动反应可能不是主要由视觉驱动的。这些结果为不同细胞类型在更广泛的感觉和运动相互作用的分布式网络中所扮演的角色提供了深入的了解。
