Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Beijing, China.
Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
Ann Med. 2023;55(2):2246370. doi: 10.1080/07853890.2023.2246370.
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by autoantibody production, joint inflammation and bone destruction. Nearly 1/3 of RA patients with the active disease also exhibit a normal range of ESR and CRP. Here we assessed the performance and clinical significance of soluble CD24 (sCD24) as a biomarker of disease activity in RA. A total of 269 RA patients, 59 primary Sjogren's syndrome (SS) patients, 81 systematic lupus erythematosus (SLE) patients, 76 osteoarthritis (OA) patients and 97 healthy individuals (HC) were included in this study. Soluble CD24 in sera were detected by ELISA. Therefore, the concentration of sCD24 was analyzed in RA patients with different disease activity statuses. The sCD24 was significantly increased in RA (2970 pg/mL), compared to other rheumatic diseases (380-520 pg/mL) and healthy individuals (320 pg/mL). Moreover, sCD24 was elevated in 66.67% of early RA and 61.11% of seronegative RA patients. In addition, sCD24 was significantly correlated with the disease duration and inflammatory indicators. The sCD24 could be an inflammatory biomarker in RA patients, especially in early and seronegative patients.
类风湿关节炎（RA）是一种慢性、系统性自身免疫性疾病，其特征为自身抗体产生、关节炎症和骨破坏。近 1/3 的活动期 RA 患者的 ESR 和 CRP 也在正常范围内。在这里，我们评估了可溶性 CD24（sCD24）作为 RA 疾病活动生物标志物的性能和临床意义。本研究共纳入 269 例 RA 患者、59 例原发性干燥综合征（SS）患者、81 例系统性红斑狼疮（SLE）患者、76 例骨关节炎（OA）患者和 97 名健康对照者（HC）。采用 ELISA 法检测血清中可溶性 CD24。因此，分析了不同疾病活动状态下 RA 患者的 sCD24 浓度。与其他风湿性疾病（380-520pg/ml）和健康对照者（320pg/ml）相比，RA 患者的 sCD24（2970pg/ml）明显升高。此外，早期 RA 和血清阴性 RA 患者中 sCD24 升高分别占 66.67%和 61.11%。此外，sCD24 与疾病持续时间和炎症指标显著相关。sCD24 可能是 RA 患者的一种炎症生物标志物，尤其是在早期和血清阴性患者中。
Zotero 插件