Turner M C, DeQuattro V, Falk R, Ansari A, Lieberman E
Hypertension. 1986 Oct;8(10):851-8. doi: 10.1161/01.hyp.8.10.851.
Childhood familial pheochromocytoma was investigated in four patients by abdominal computed tomographic scan, [131I]metaiodobenzylguanidine scan, and vena caval catecholamine sampling. Results conflicted with surgical findings. Computed tomographic scan identified all four adrenal tumors but missed two midline tumors in one patient. [131I]metaiodobenzylguanidine scan identified two of three adrenal tumors but also suggested extra-adrenal tumors not confirmed at operation in two of three patients. Vena caval sampling for catecholamines confirmed all adrenal tumors but suggested additional tumors not verified at operation in two of three patients. All patients are asymptomatic and have normal urinary catecholamines 15 to 51 months after operation. Because of the frequency of multiple tumors in familial pheochromocytoma, different diagnostic techniques were employed. False-positive results were more frequent with [131I]metaiodobenzylguanidine and vena caval sampling. Reinterpretation of the [131I]metaiodobenzylguanidine scans at a later date led to less false-positive interpretation, although the false-negative rate remained unchanged. More pediatric experience with [131I]metaiodobenzylguanidine scans and vena caval sampling in familial pheochromocytoma is needed. Confirmation of tumor and its localization rest with meticulous surgical exploration.
通过腹部计算机断层扫描、[131I]间碘苄胍扫描和腔静脉儿茶酚胺采样对4例儿童家族性嗜铬细胞瘤患者进行了研究。结果与手术所见不一致。计算机断层扫描识别出了所有4个肾上腺肿瘤，但有1例患者漏诊了2个中线肿瘤。[131I]间碘苄胍扫描识别出了3个肾上腺肿瘤中的2个，但也提示3例患者中有2例存在手术中未证实的肾上腺外肿瘤。腔静脉儿茶酚胺采样证实了所有肾上腺肿瘤，但提示3例患者中有2例存在手术中未证实的其他肿瘤。所有患者均无症状，术后15至51个月尿儿茶酚胺水平正常。由于家族性嗜铬细胞瘤中多发肿瘤的发生率较高，因此采用了不同的诊断技术。[131I]间碘苄胍和腔静脉采样的假阳性结果更为常见。后期对[131I]间碘苄胍扫描结果的重新解读减少了假阳性解读，尽管假阴性率保持不变。在家族性嗜铬细胞瘤中，需要更多关于[131I]间碘苄胍扫描和腔静脉采样的儿科经验。肿瘤及其定位的确认依赖于细致的手术探查。
