Department of Magnetic Resonance Imaging, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Key Laboratory for Functional Magnetic Resonance Imaging of Henan Province, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Eur J Neurosci. 2023 Sep;58(6):3531-3539. doi: 10.1111/ejn.16117. Epub 2023 Aug 17.
Prior studies suggest that obsessive-compulsive disorder (OCD) can cause both anatomical and functional variations in the brain, but to date, altered functional synchronization between two functional hemispheres remains unclear in OCD patients. Voxel-mirrored homotopic connectivity (VMHC) is defined as the temporal correlation of spontaneous low-frequency blood oxygenation level-dependent signal fluctuations across mirror regions of hemisphere revealing the homotopic connectivity between each voxel in one hemisphere and its mirrored counterpart in the contralateral hemisphere. To investigate the alterations of brain regional function and VMHC in patients with OCD, the current study enrolled 103 OCD patients and 118 healthy controls, undergoing resting-state functional magnetic resonance imaging. Compared to healthy controls (HCs), patients had decreased VMHC in bilateral cerebellum, lingual and fusiform gyrus; bilateral paracentral lobule, pre and postcentral gyrus; and bilateral superior and middle temporal gyrus, putamen and bilateral precuneus without global signal regression. And we found mostly similar results after regressing global signals; apart from the regions mentioned above, decreased in bilateral cuneus and calcarine was also showed. Furthermore, the mean VMHC values of the left cerebellum were negatively correlated with the obsession scores (ρ = -.204, π = .039). The decreased values in right fusiform and putamen were negatively correlated with duration of disease (ρ = -.205, π = .038; ρ = -.196, π = .047). We confirmed a significant VMHC reduction in OCD patients in broad areas. Our findings suggest that the patients tend to disconnect information exchange across hemispheres.
先前的研究表明，强迫症（OCD）可能导致大脑的解剖和功能发生变化，但迄今为止，OCD 患者两个功能半球之间的功能同步变化仍不清楚。体素镜像同形同频连接（VMHC）被定义为半球镜像区域之间自发低频血氧水平依赖信号波动的时间相关性，揭示了一个半球中每个体素与其对侧半球镜像体素之间的同形同频连接。为了研究 OCD 患者大脑区域功能和 VMHC 的变化，本研究纳入了 103 名 OCD 患者和 118 名健康对照者，进行静息态功能磁共振成像。与健康对照组（HCs）相比，患者双侧小脑、舌回和梭状回、双侧旁中央小叶、额、顶、中央回以及双侧颞上、中回、壳核和双侧楔前叶 VMHC 降低，未进行全局信号回归。在回归全局信号后，我们发现了类似的结果；除了上述区域外，双侧楔叶和舌回也显示出降低。此外，左侧小脑的平均 VMHC 值与强迫症状评分呈负相关（ρ=-0.204，π=0.039）。右侧梭状回和壳核的 VMHC 值降低与疾病持续时间呈负相关（ρ=-0.205，π=0.038；ρ=-0.196，π=0.047）。我们在广泛的区域证实了 OCD 患者 VMHC 的显著减少。我们的研究结果表明，患者倾向于中断大脑半球之间的信息交换。
