Jia Cuicui, Ou Yangpan, Chen Yunhui, Li Ping, Lv Dan, Yang Ru, Zhong Zhaoxi, Sun Lei, Wang Yuhua, Zhang Guangfeng, Guo Hong, Sun Zhenghai, Wang Wei, Wang Yefu, Wang Xiaoping, Guo Wenbin
Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China.
Front Psychiatry. 2020 Sep 15;11:559729. doi: 10.3389/fpsyt.2020.559729. eCollection 2020.
Decreased homotopic connectivity of brain networks such as the cortico-striato-thalamo-cortical (CSTC) circuits may contribute to the pathophysiology of obsessive-compulsive disorder (OCD). However, little is known about interhemispheric functional connectivity (FC) at rest in OCD. In this study, the voxel-mirrored homotopic connectivity (VMHC) method was applied to explore interhemispheric coordination at rest in OCD.
Forty medication-free patients with OCD and 38 sex-, age-, and education level-matched healthy controls (HCs) underwent a resting-state functional magnetic resonance imaging. The VMHC and support vector machine (SVM) methods were used to analyze the data.
Patients with OCD had remarkably decreased VMHC values in the orbitofrontal cortex, thalamus, middle occipital gyrus, and precentral and postcentral gyri compared with HCs. A combination of the VMHC values in the thalamus and postcentral gyrus could optimally distinguish patients with OCD from HCs.
Our findings highlight the contribution of decreased interhemispheric FC within and outside the CSTC circuits in OCD and provide evidence to the pathophysiology of OCD.
大脑网络如皮质-纹状体-丘脑-皮质（CSTC）回路的同位连接性降低可能导致强迫症（OCD）的病理生理过程。然而，关于强迫症患者静息状态下的半球间功能连接（FC）知之甚少。在本研究中，采用体素镜像同位连接性（VMHC）方法来探究强迫症患者静息状态下的半球间协调性。
40例未服用药物的强迫症患者和38例性别、年龄及教育水平相匹配的健康对照者（HCs）接受了静息态功能磁共振成像检查。采用VMHC和支持向量机（SVM）方法对数据进行分析。
与健康对照者相比，强迫症患者在眶额皮质、丘脑、枕中回以及中央前回和中央后回的VMHC值显著降低。丘脑和中央后回的VMHC值组合能够最佳地区分强迫症患者和健康对照者。
我们的研究结果突出了强迫症患者CSTC回路内外半球间FC降低的作用，并为强迫症的病理生理学提供了证据。
