Seetharam Smitha Pernaje, Shankar Vinutha, Udupa Kaviraja, Anjanappa Raveesha, Reddy Niranjan
Department of Physiology, Sapthagiri Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India.
Department of Physiology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India.
J Clin Transl Res. 2023 Jul 26;9(4):265-271. eCollection 2023 Aug 31.
Assessment of health-related quality of life (HRQoL) is an important measure of a patient's recovery after an illness. However, HRQoL among acute coronary syndrome (ACS) survivors has not been extensively studied following cardiac management.
The purpose of this study was to assess the quality of life (QoL) among ACS patients who have undergone percutaneous coronary intervention (PCI).
This cohort study included 145 consecutive male ACS patients between March 2021 and May 2022. Of these patients, 138 (mean age 54.3 ± 10.7 years) completed the QoL assessment using the short form-12 (SF-12) health survey questionnaire. Seventy (51%) of them presented with ST-segment elevation myocardial infarction (STEMI), 18 (13%) had non-STEMI, 39 (28%) had evolved MI, and 11 (8%) had unstable angina. Recruited patients' QoL data were assessed at various time points post-PCI.
At the end of the 12 months of follow-up, major clinical events (MCE) defined as death, sudden death, or re-acute myocardial infarction occurred in 54.9% of patients. Out of 7 MCE, four deaths and three re-AMIs had occurred. SF-12 physical component score was found to be significantly improved when compared to the mental component score, which seems to improve without reaching statistical significance over time. Among event-free ACS patients, we found a significant positive correlation between left ventricular ejection fraction and HRQoL.
Improvement in HRQoL (physical component) was seen among ACS patients post-PCI.
QoL assessment outcomes should be considered in clinical settings, practice guidelines, and treatment modality post-PCI to improve QoL in post-ACS survivors.
健康相关生活质量（HRQoL）评估是衡量患者疾病康复情况的一项重要指标。然而，急性冠状动脉综合征（ACS）幸存者的HRQoL在心脏管理后的研究并不广泛。
本研究旨在评估接受经皮冠状动脉介入治疗（PCI）的ACS患者的生活质量（QoL）。
这项队列研究纳入了2021年3月至2022年5月期间连续的145例男性ACS患者。其中，138例（平均年龄54.3±10.7岁）使用简短健康调查问卷12项（SF-12）完成了QoL评估。其中70例（51%）表现为ST段抬高型心肌梗死（STEMI），18例（13%）为非STEMI，39例（28%）为陈旧性心肌梗死，11例（8%）为不稳定型心绞痛。在PCI术后的不同时间点对招募患者的QoL数据进行评估。
在12个月的随访结束时，54.9%的患者发生了定义为死亡、猝死或再急性心肌梗死的主要临床事件（MCE）。在7例MCE中，发生了4例死亡和3例再发急性心肌梗死。与心理成分评分相比，SF-12身体成分评分有显著改善，心理成分评分随时间推移似乎有所改善，但未达到统计学意义。在无事件的ACS患者中，我们发现左心室射血分数与HRQoL之间存在显著正相关。
PCI术后ACS患者的HRQoL（身体成分）有所改善。
在临床环境、实践指南和PCI术后治疗方式中应考虑QoL评估结果，以改善ACS后幸存者的QoL。
