Levitsky D A, Schuster J A, Stallone D, Strupp B J
Int J Obes. 1986;10(3):169-73.
The thermogenic effect of fenfluramine was examined in rats following either fasting or the ingestion of a large meal. Fenfluramine did not produce a thermogenic effect in the fasting animal, but significantly potentiated the thermogenic effect of the meal. Furthermore, fenfluramine was found to produce a significant thermogenic effect when accompanied with a glucose meal, but not with one consisting of fat. These data demonstrate the importance of drug and nutrient interactions in the analysis of thermogenesis and suggest that substrate cycling may play a role in the thermogenic effect of fenfluramine.
在禁食或摄入大量食物后的大鼠中研究了芬氟拉明的产热效应。芬氟拉明在禁食动物中未产生产热效应，但显著增强了食物的产热效应。此外，发现芬氟拉明与葡萄糖餐一起时会产生显著的产热效应，但与脂肪餐一起时则不会。这些数据证明了药物与营养素相互作用在产热分析中的重要性，并表明底物循环可能在芬氟拉明的产热效应中起作用。
