Kamil Sally, Sweeney Eva, Darwish Nagy
School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, GBR.
Care of the Elderly, Glan Clwyd Hospital, Rhyl, GBR.
Cureus. 2023 Jul 17;15(7):e42034. doi: 10.7759/cureus.42034. eCollection 2023 Jul.
Introduction Osteoid osteoma is a benign condition of the bone, usually affecting young males. This retrospective study explores the demographics of osteoid osteomas in the Northern Irish population. It also aims to audit the practice of CT-guided radiofrequency ablation of osteoid osteomas at a major orthopaedic centre in Belfast, Northern Ireland, and to investigate the possible causes of treatment failure. Methods Forty-seven osteoid osteoma patients, diagnosed based on clinico-radiologic features and treated with CT-guided radiofrequency ablation, were found eligible for inclusion and analysis. We collected data from electronic health records (March 2011 to May 2022) and reviewed the radiological images and associated reports. Information about demographics, clinical indices, operative technique, clinical outcomes, biopsy results, and follow-up were also gathered. Data were then analysed using IBM SPSS Statistics for Mac, version 28.0.1.1 (14) (IBM Corp., Armonk, NY). Results The average age of patients was 19.3 years, with a male-to-female predilection of 2.1:1. The proximal and mid-tibial shafts were the most frequently involved sites. On average, patients had symptoms for 15.6 months, while the mean treatment delay period was 6.9 months. Primary clinical success was observed in 37 patients (78.7%), while ten patients had a clinical failure. Two out of the 10 patients with treatment failure underwent subsequent successful ablations, raising the secondary clinical success rate to (83.0%). Chi-Square association tests found no correlation between primary treatment outcomes and other qualitative variables (gender, bone type, lesion location, and Kayser classification). Moreover, binary logistic regression tests found no predictability of age and treatment delay on treatment outcomes. The overall observed complication rate was 4%, with only one significant side effect reported (third-degree skin burn). Conclusion We concluded that the demographics of osteoid osteomas in the Northern Irish population are comparable to what is previously established in the literature. Furthermore, we reasoned that CT-guided radiofrequency ablation is an efficient, safe, and effective minimally invasive technique in the management of osteoid osteomas.
引言
骨样骨瘤是一种良性骨病,通常影响年轻男性。本回顾性研究探讨了北爱尔兰人群中骨样骨瘤的人口统计学特征。它还旨在审核北爱尔兰贝尔法斯特一家主要骨科中心对骨样骨瘤进行CT引导下射频消融的实践情况,并调查治疗失败的可能原因。
方法
基于临床放射学特征诊断并接受CT引导下射频消融治疗的47例骨样骨瘤患者符合纳入和分析标准。我们从电子健康记录(2011年3月至2022年5月)中收集数据,并复查放射影像及相关报告。还收集了有关人口统计学、临床指标、手术技术、临床结果、活检结果及随访的信息。然后使用IBM SPSS Statistics for Mac 28.0.1.1(14)版软件(IBM公司,纽约州阿蒙克)对数据进行分析。
结果
患者的平均年龄为19.3岁,男女比例为2.1:1。胫骨近端和中段是最常受累部位。患者平均有症状15.6个月,平均治疗延迟期为6.9个月。37例患者(78.7%)观察到初次临床成功,10例患者临床失败。10例治疗失败的患者中有2例随后成功进行了消融,使二次临床成功率提高到83.0%。卡方关联检验发现初次治疗结果与其他定性变量(性别、骨类型、病变部位和凯泽分类)之间无相关性。此外,二元逻辑回归检验发现年龄和治疗延迟对治疗结果无预测性。总体观察到的并发症发生率为4%,仅报告了1例严重副作用(三度皮肤烧伤)。
结论
我们得出结论,北爱尔兰人群中骨样骨瘤的人口统计学特征与先前文献中所确立的情况相当。此外,我们推断CT引导下射频消融是治疗骨样骨瘤的一种高效、安全且有效的微创技术。