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雌激素暴露时间并不影响人工周期的生殖结局：对 7000 多个胚胎移植用激素替代治疗周期的回顾性分析。

Duration of oestrogen exposure does not affect reproductive outcome in artificial cycles: a retrospective analysis of more than 7000 hormonal replacement therapy cycles for an embryo transfer.

机构信息

Valencian Infertility Institute (IVI) Foundation - Health Research Institute (IIS) La Fe, Valencia, Spain.

Human Reproduction Department, Valencian Infertility Institute (IVI) Reproductive Medicine Associates (RMA) Valencia, Valencia, Spain.

出版信息

Front Endocrinol (Lausanne). 2023 Aug 1;14:1233685. doi: 10.3389/fendo.2023.1233685. eCollection 2023.

DOI:10.3389/fendo.2023.1233685
PMID:37593348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10430777/
Abstract

INTRODUCTION

Optimal duration of oestrogen exposure before an embryo transfer in artificial cycles has not been defined yet, as its correlation with reproductive outcome remains controversial. The length of oestrogen treatment before starting luteal phase support varies significantly among patients.

MATERIALS AND METHODS

In this study, we conducted a retrospective analysis of a huge database of our own clinical results in artificial cycles in the past five years. The aim of this study was to assess the effect of the length of estrogen exposure on reproductive outcome and to evaluate if there is any optimal duration of estrogen exposure in order to maximize success rates.

RESULTS

Differences in pregnancy rates according to oestrogen length, if present, were not clinically relevant.

DISCUSSION

Our results suggest that the length of oestrogen exposure (in days) before exogenous progesterone administration do not affect clinical outcomes.

摘要

简介

在人工周期中，胚胎移植前的最佳雌激素暴露时间尚未确定，因为其与生殖结局的相关性仍存在争议。开始黄体期支持前的雌激素治疗时间在患者之间差异很大。

材料与方法

本研究对过去五年我们在人工周期中的大量临床结果数据库进行了回顾性分析。本研究的目的是评估雌激素暴露时间对生殖结局的影响，并评估是否存在最佳的雌激素暴露时间，以最大限度地提高成功率。

结果

根据雌激素长度（如果存在）的妊娠率差异在临床上并不相关。

讨论

我们的结果表明，外源性孕激素给药前的雌激素暴露（天数）长度不会影响临床结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d9/10430777/ea66988583c4/fendo-14-1233685-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d9/10430777/ea66988583c4/fendo-14-1233685-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d9/10430777/ea66988583c4/fendo-14-1233685-g001.jpg

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本文引用的文献

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J Ovarian Res. 2022 Mar 21;15(1):36. doi: 10.1186/s13048-022-00967-5.
2
The timing for initiating estrogen stimulation in artificial cycle for frozen-thawed embryo transfer can be flexible.冻融胚胎移植中人工周期雌激素刺激的启动时间可以灵活掌握。
Reprod Health. 2021 Sep 9;18(1):181. doi: 10.1186/s12978-021-01229-1.
3
Impact of low serum progesterone levels on the day of embryo transfer on pregnancy outcome: a prospective cohort study in artificial cycles with vaginal progesterone.
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