Borini A, Dal Prato L, Bianchi L, Violini F, Cattoli M, Flamigni C
Tecnobios, Center for Reproductive Health, Via Dante 15, I-40125 Bologna, Italy.
J Assist Reprod Genet. 2001 Apr;18(4):185-90. doi: 10.1023/a:1009472416305.
To investigate if duration of estrogenic endometrial stimulation can affect recipient pregnancy rate in an ovum donation program.
Each recipient received micronized 17 beta-estradiol orally in a steadily increasing dosage from 2 to 6 mg daily over a period of time varying from 5 to 76 days until oocyte were available for donation. Recipients (520 patients for a total of 835 transfer cycles) were retrospectively divided into five groups depending on the duration of E2 administration.
No significant difference was seen in pregnancy and implantation rates between groups. There was a higher number of miscarriages in Group A (41%), p < 0.05 vs. Group B (15%), and vs. Group E (1%). Age, number of pregnancies and miscarriages, or implantation rate in donors (327 women aged < 35 years) were similar in all the five groups.
Endometrial receptivity is tolerant to a wide duration of E2 treatment (until 2 months), while waiting for oocytes available for donation, but best results are achieved with a treatment range of 11 to about 40 days.
研究在卵子捐赠项目中，雌激素对子宫内膜刺激的持续时间是否会影响受体的妊娠率。
每位受体口服微粉化17β-雌二醇，剂量从每日2毫克稳步增加至6毫克，持续时间从5天到76天不等，直至有可用于捐赠的卵母细胞。根据雌二醇给药持续时间，将受体（共835个移植周期的520名患者）回顾性地分为五组。
各组之间的妊娠率和着床率无显著差异。A组的流产率较高（41%），与B组（15%）相比，p<0.05，与E组（1%）相比也有差异。所有五组中，供体（327名年龄小于35岁的女性）的年龄、妊娠次数和流产次数或着床率相似。
在等待可用于捐赠的卵母细胞时，子宫内膜容受性对雌二醇治疗的较长持续时间（直至2个月）具有耐受性，但治疗时间在11至约40天范围内可取得最佳效果。
