Houghten R A, Bray M K, Degraw S T, Kirby C J
Int J Pept Protein Res. 1986 Jun;27(6):673-8. doi: 10.1111/j.1399-3011.1986.tb01064.x.
Methods have recently been presented which greatly increase the ability to synthesize large numbers of peptides. These advances make it essential to be able to cleave large numbers of protected peptide resins. Two different procedures are presented for carrying out cleavage of protected peptide resins. The first procedure enables multiple cleavages to be carried out with many existing HF apparatuses, while the second utilizes a new apparatus design. Using these procedures, at least 50 individual cleavages can be carried out per day.
最近已经提出了一些方法，这些方法大大提高了合成大量肽的能力。这些进展使得能够裂解大量受保护的肽树脂变得至关重要。本文介绍了两种不同的用于裂解受保护肽树脂的方法。第一种方法能够使用许多现有的氢氟酸（HF）设备进行多次裂解，而第二种方法则采用了一种新的设备设计。使用这些方法，每天至少可以进行50次单独的裂解。
