Yuce Ahmet, Keles Mevlut, Benli Erdal, Cirakoglu Abdullah, Yazici Ibrahim, Nalbant Ismail
Department of Urology, Darende Hulusi Efendi State Hospital, Malatya, Turkey.
Department of Urology, Ordu University, Faculty of Medicine, Ordu, Turkey.
Iran J Public Health. 2023 Jul;52(7):1487-1494. doi: 10.18502/ijph.v52i7.13251.
Prostate cancer (PCa) is the most common cancer affecting men, apart from cutaneous cancers. Serum prostate specific antigen (PSA) levels are frequently used to predict prostate cancer diagnosis. However, many causes (e.g., prostatitis, benign prostate obstruction, urethral catheterization) may cause elevated PSA, in addition to PCa. We aimed to investigate the gamma glutamyl transferase (GGT) levels, a serum biomarker not affected by situations other than cancer causing elevated PSA.
The study evaluated male patients with prostate biopsy due to high serum PSA levels and/or abnormal digital rectal examination (DRE) examined in Ordu University Education and Research Hospital, Ordu/Turkey urology clinic from April 2019 to April 2021. The patient group in the study included 261 men with PCa diagnosis and the control group included 245 healthy men with normal PSA levels, and no PCa and/or benign prostate obstruction (BPO). The two groups were compared in terms of serum GGT levels.
GGT was significantly low in the PCa group and might be a predictor in terms of PCa (=0.000). In the malignant (PCa) group, the GGT cut-off value was identified as 21.5 (sensitivity 68.6%, specificity 54.4%).
Serum GGT levels might assist in diagnosis of PCa. However, diagnostic power is weak due to low specificity. There is a need for studies investigating the efficacy of GGT levels for prediction of PCa diagnosis and assessing other parameters alongside GGT.
前列腺癌（PCa）是除皮肤癌外影响男性最常见的癌症。血清前列腺特异性抗原（PSA）水平常用于预测前列腺癌的诊断。然而，除了PCa之外，许多原因（如前列腺炎、良性前列腺梗阻、尿道插管）都可能导致PSA升高。我们旨在研究γ-谷氨酰转移酶（GGT）水平，这是一种不受除癌症以外导致PSA升高情况影响的血清生物标志物。
该研究评估了2019年4月至2021年4月在土耳其奥尔杜市奥尔杜大学教育与研究医院泌尿外科门诊因血清PSA水平高和/或直肠指检（DRE）异常而接受前列腺活检的男性患者。研究中的患者组包括261名诊断为PCa的男性，对照组包括245名PSA水平正常、无PCa和/或良性前列腺梗阻（BPO）的健康男性。比较了两组的血清GGT水平。
PCa组的GGT显著降低，可能是PCa的一个预测指标（P = 0.000）。在恶性（PCa）组中，GGT的临界值确定为21.5（敏感性68.6%，特异性54.4%）。
血清GGT水平可能有助于PCa的诊断。然而，由于特异性较低，诊断能力较弱。需要开展研究来调查GGT水平对预测PCa诊断的有效性，并评估GGT以外的其他参数。
