Meenakshi R P, Kiruba R, Arun K V, Sivaram G, Arumuganainar Deepavalli, Kaveri K
Dr. M.G.R. Medical University, Chennai, Tamil Nadu, India.
Department of Virology, Kings Institute of Preventive Medicine and Research, Chennai, Tamil Nadu, India.
J Indian Soc Periodontol. 2023 Jul-Aug;27(4):437-442. doi: 10.4103/jisp.jisp_436_22. Epub 2023 Jul 1.
Miller's Class III gingival recessions (GRs) have always posed a challenge to the clinicians in terms of achieving complete root coverage (CRC). In the present case, a cell-based therapy with autologous fibroblasts seeded onto a Type 1 collagen membrane, through an culturing method was utilized. The fibroblasts-seeded membrane was surgically placed under a laterally repositioned flap. The patient presented with a CRC, which was stable even at the postoperative period of 45 months. In addition, a 3-mm substantial gain in the width of keratinized tissue was achieved and maintained throughout the postoperative period. Hence, the results of the cell-seeded therapy emphasize that it can serve as an effective alternative method for the management of Miller's Class III GRs.
米勒Ⅲ类牙龈退缩（GRs）在实现完全根面覆盖（CRC）方面一直给临床医生带来挑战。在本病例中，采用了一种通过培养方法将自体成纤维细胞接种到Ⅰ型胶原膜上的细胞疗法。将接种有成纤维细胞的膜手术放置在侧向复位瓣下方。患者实现了完全根面覆盖，即使在术后45个月时仍保持稳定。此外，在术后整个期间角化组织宽度显著增加了3毫米并得以维持。因此，细胞接种疗法的结果强调，它可作为治疗米勒Ⅲ类牙龈退缩的一种有效替代方法。
