Department of Environmental Sciences, Kinshasa University (UNIKIN), Kinshasa XI, BP 127, Kinshasa, Democratic Republic of Congo.
Laboratory of Tropical and Subtropical Agriculture and Ethnobotany, Ghent University, Coupure Links 653, B-9000, Ghent, Belgium.
Chem Biodivers. 2023 Sep;20(9):e202300826. doi: 10.1002/cbdv.202300826. Epub 2023 Sep 8.
Kalaharia uncinata (Schinz) Moldenke, is a tropical erect bushy shrub or subshrub of the Lamiaceae family. It is an endemic plant species of Southern Africa, widely used in the pharmacopoeia against upper respiratory tract infections. A previously conducted ethnobotanical survey revealed that it is believed to contain bioactive substances. However, no relevant phytochemical information was available. This study aimed to perform a phytochemical characterization of K. uncinata and also to discuss the potential bioactivity of the identified phytochemical constituents based on documented data. Ultra-performance liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOF-MS) was used for profiling and identification of the main phytochemical constituents from leaf extracts (MeOH 90 %, DCM, AcOEt, BuOH, hexane and residue) of K.uncinata. Twenty-four constituents, representing mainly flavonoids (14), followed by phenylethanoid glycosides (7), phenolic acids (2), and an iridoid glycoside (1) were tentatively identified. Most of the identified compounds are documented to have antiviral and anti-inflammatory properties, which could possibly be the rationale behind the use of K. uncinata against upper respiratory tract infections.
弯叶蜡菊（Schinz）Moldenke 是唇形科的一种热带直立丛生灌木或亚灌木。它是南非特有的植物物种，广泛用于治疗上呼吸道感染的药物。先前进行的民族植物学调查显示，人们认为它含有生物活性物质。然而，目前还没有相关的植物化学信息。本研究旨在对弯叶蜡菊进行植物化学表征，并根据已有的文献数据讨论鉴定出的植物化学成分的潜在生物活性。采用超高效液相色谱-电喷雾电离四极杆飞行时间质谱联用（UPLC-ESI-QTOF-MS）对弯叶蜡菊叶提取物（90%MeOH、DCM、AcOEt、BuOH、正己烷和残渣）中的主要植物化学成分进行分析和鉴定。共鉴定出 24 种成分，主要为类黄酮（14 种），其次为苯乙醇苷（7 种）、酚酸（2 种）和环烯醚萜苷（1 种）。大多数鉴定出的化合物具有抗病毒和抗炎特性，这可能是弯叶蜡菊用于治疗上呼吸道感染的理论依据。
