Division of Convergence on Marine Science, Korea Maritime & Ocean University, Busan, 49112, Korea.
Incheon Regional Office, National Fishery Products Quality Management Service (NFQS), Incheon, 22346, Korea.
Comb Chem High Throughput Screen. 2024;27(3):446-454. doi: 10.2174/1386207326666230818092719.
The objective of this study was to determine the effects of intake of polyphenols from on spatial task performance and nervous fatty acid composition in mice fed with a high-fat diet.
Thirty mice were randomly divided into three groups; each group consisted of ten mice. The control group was fed 5% soybean oil as a fat source, whereas the high fat (HF) group was fed a 15% lard diet and the polyphenol (ECP) group was maintained on the HF diet plus 1% polyphenols.
The ECP group exhibited a short escape latency and better memory retention in the Morris water maze test compared with the control and HF groups (P<0.05). In addition, the ECP group showed a greater increase in avoidance latency than that of the HF group (P<0.05). Moreover, the consumption of polyphenols from presented higher levels of DHA in the brain and retina (P<0.05).
This study suggested the positive effects of polyphenols from E. cava on memory retention, which might be partially attributed to the increased levels of DHA in the brain.
本研究旨在确定从 中摄取多酚对高脂肪饮食喂养的小鼠空间任务表现和神经脂肪酸组成的影响。
将 30 只小鼠随机分为三组，每组 10 只。对照组以 5%大豆油作为脂肪来源，而高脂肪（HF）组以 15%猪油饮食喂养，多酚（ECP）组则维持在 HF 饮食加 1%多酚。
与对照组和 HF 组相比，ECP 组在 Morris 水迷宫测试中表现出较短的逃避潜伏期和更好的记忆保留（P<0.05）。此外，ECP 组的回避潜伏期比 HF 组增加更多（P<0.05）。此外，从 中摄取多酚可使大脑和视网膜中的 DHA 水平升高（P<0.05）。
本研究表明，来自 E. cava 的多酚对记忆保留有积极作用，这可能部分归因于大脑中 DHA 水平的增加。
