Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Shandong Provincial Key laboratory of Glycoscience and Glycoengineering, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine, Science and Technology, Qingdao 266237, China.
ACS Appl Mater Interfaces. 2023 Aug 30;15(34):40267-40279. doi: 10.1021/acsami.3c08368. Epub 2023 Aug 18.
Transdermal cancer therapy faces great challenges in clinical practice due to the low drug transdermal efficiency and the unsatisfactory effect of monotherapy. Herein, we develop a novel bubble pump microneedle system (BPMN-CuS/DOX) by embedding sodium bicarbonate (NaHCO) into hyaluronic acid microneedles (MNs) loaded with fucoidan-based copper sulfide nanoparticles (Fuc-CuS NPs) and doxorubicin (DOX). BPMN-CuS/DOX can generate CO bubbles triggered by an acidic tumor microenvironment for deep and rapid intradermal drug delivery. Fuc-CuS NPs exhibit excellent photothermal effect and Fenton-like catalytic activity, producing more reactive oxygen species (ROS) by photothermal therapy (PTT) and chemodynamic therapy (CDT), which enhances the antitumor efficacy of DOX and reduces the dosage of its chemotherapy (CT). Simultaneously, DOX increases intracellular hydrogen peroxide (HO) supplementation and promotes the sustained production of ROS. BPMN-CuS/DOX significantly inhibits melanoma both and by the combination of CDT, PTT, and CT. In short, our study significantly enhances the effectiveness of transdermal drug delivery by constructing BPMNs and provides a promising novel strategy for transdermal cancer treatment with multiple therapies.
透皮癌症治疗在临床实践中面临着巨大的挑战，这是由于药物透皮效率低和单药治疗效果不理想所致。在此，我们通过将碳酸氢钠（NaHCO）嵌入负载基于褐藻胶的硫化铜纳米粒子（Fuc-CuS NPs）和阿霉素（DOX）的透明质酸微针（MNs）中，开发了一种新型的气泡泵微针系统（BPMN-CuS/DOX）。BPMN-CuS/DOX 可以在酸性肿瘤微环境中产生 CO 气泡，从而实现深部和快速的皮内药物输送。Fuc-CuS NPs 表现出优异的光热效应和类芬顿催化活性，通过光热治疗（PTT）和化学动力学治疗（CDT）产生更多的活性氧（ROS），增强了 DOX 的抗肿瘤功效，并降低了其化疗（CT）的剂量。同时，DOX 增加了细胞内过氧化氢（HO）的补充，并促进了 ROS 的持续产生。BPMN-CuS/DOX 通过 CDT、PTT 和 CT 的联合显著抑制了黑色素瘤的 和 。总之，我们的研究通过构建 BPMNs 显著提高了透皮药物输送的效果，并为多疗法透皮癌症治疗提供了一种有前途的新策略。
