Department of Stomatology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
School of Medicine, University of Electronic Science and Technology of Chengdu, Sichuan, China.
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):441-452. doi: 10.1080/21691401.2023.2244013.
High translucent zirconia (HTZ) has excellent mechanical properties, biocompatibility, and good semi-translucency making it an ideal material for aesthetic anterior dental implant abutments without antibacterial properties. In the oral environment, the surface of the abutment material is susceptible to microbial adhesion and biofilm formation, which can lead to infection or peri-implantitis and even implant failure. This study aims to promote the formation of a biological seal at the implant-soft tissue interface by modifying the HTZ surface, using the load-bearing capacity of the aluminosilicate porous structure and the broad-spectrum antibacterial effect of silver nanoparticles to prevent peri-implant bacterial infection and inflammation and to improve the success rate and prolong the use of the implant. FE-SEM (field emission scanning electron microscopes), EDS (energy dispersive spectroscopy), and XPS (X-ray photoelectron spectroscopy) results showed that aluminosilicate non-vacuum sintering can form open micro- and nanoporous structures on HTZ surfaces, and that porous aluminosilicate coatings obtain a larger number, smaller size, and more uniformly shaped silver nanoparticles than smooth aluminosilicate coatings, and could be deposited deeper in the coating. The ICP-AES (inductively coupled plasma-atomic emission spectroscopy) results showed that the early silver ion release of both the smooth silver coating and the porous silver coating was obvious, the silver ion concentration released by the former was higher than that of the latter. However, the silver ion concentration released by the porous silver coating was higher than that of the smooth coating when the release slowed down. Both smooth and porous silver coatings both inhibited (), (), and (), and porous silver coatings had stronger antibacterial properties. The silver coating was successfully constructed on the surface of HTZ, through aluminium silicate sintering and silver nitrate solution impregnation. It was found that the high concentration environment of silver nitrate solution was more advantageous for nano-Ag deposition, and the non-vacuum sintered porous surface was able to obtain a larger number of nano-Ag particles with smaller sizes. The porous Ag coating exhibited superior antibacterial properties. It was suggested that the HTZ with silver coating had clinical application, and good antibacterial properties that can improve the survival rate and service life of implants.
高透明度氧化锆(HTZ)具有优异的机械性能、生物相容性和良好的半透明度,是一种理想的用于美观的前牙种植体基台的材料,但它没有抗菌性能。在口腔环境中,基台材料的表面容易受到微生物的黏附以及生物膜的形成,这可能导致感染或种植体周围炎,甚至种植体失败。本研究旨在通过修饰 HTZ 表面来促进种植体-软组织界面的生物密封形成,利用铝硅酸盐多孔结构的承载能力和纳米银的广谱抗菌作用来预防种植体周围的细菌感染和炎症,提高种植体的成功率并延长其使用寿命。FE-SEM(场发射扫描电子显微镜)、EDS(能谱仪)和 XPS(X 射线光电子能谱)结果表明,铝硅酸盐非真空烧结可以在 HTZ 表面形成开放的微纳米多孔结构,多孔铝硅酸盐涂层比光滑的铝硅酸盐涂层获得更多数量、更小尺寸且更均匀形状的纳米银颗粒,并且可以更深地沉积在涂层中。ICP-AES(电感耦合等离子体原子发射光谱)结果表明,光滑银涂层和多孔银涂层的早期银离子释放都很明显,前者释放的银离子浓度高于后者。然而,当释放速度减慢时,多孔银涂层释放的银离子浓度高于光滑涂层。无论是光滑银涂层还是多孔银涂层都能抑制金黄色葡萄球菌()、大肠杆菌()和白色念珠菌(),且多孔银涂层具有更强的抗菌性能。成功地在 HTZ 表面构建了银涂层,通过铝硅酸盐烧结和硝酸银溶液浸渍。发现硝酸银溶液的高浓度环境更有利于纳米银的沉积,非真空烧结的多孔表面能够获得更多数量、更小尺寸的纳米银颗粒。多孔银涂层表现出优异的抗菌性能。研究表明,具有银涂层的 HTZ 具有临床应用价值,并且具有良好的抗菌性能,可以提高种植体的成活率和使用寿命。