使用具有2,3-异丙叉基的d/l-核糖一锅法立体选择性合成呋喃并四氢喹啉衍生物
One-Pot Stereoselective Synthesis of Furantetrahydroquinoline Derivatives Using d/l-Ribose with a 2,3--Isopropylidene Group.
作者信息
Wu Jilai, Xie Song, Zhou Likai, Liu Yixuan, Cui Yaxin, Huang Xiaoyan, Wei Chao, Li Xiaoliu, Zhang Chunfang, Chen Hua
机构信息
Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Material Science, Hebei University, Baoding, Hebei 071002, P. R. China.
College of Chemistry and Chemical Engineering, Xingtai University, Xingtai, Hebei 054001, China.
出版信息
J Org Chem. 2023 Sep 1;88(17):12445-12450. doi: 10.1021/acs.joc.3c01187. Epub 2023 Aug 18.
An efficient and convenient strategy has been successfully developed for the preparation of novel furantetrahydroquinoline derivatives using d/l-ribose with a 2,3--isopropylidene group through the aza-Diels-Alder mechanism. This method has high atom and step economy, high stereoselectivity, and gram-scale synthesis (yield 67%).
通过氮杂狄尔斯-阿尔德机理，已经成功开发出一种高效便捷的策略，用于使用带有2,3-异亚丙基的d/l-核糖制备新型呋喃并四氢喹啉衍生物。该方法具有高原子经济性和步骤经济性、高立体选择性以及克级规模合成（产率67%）。
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